QuickView for ros1 (gene)
- Gene Symbol:
- ROS1
Homo sapiens - Full name:
- ROS proto-oncogene 1, receptor tyrosine kinase
- Synonyms:
- MCF3, ROS, c-ros-1, proto-oncogene tyrosine-protein kinase ROS, ROS proto-oncogene 1 , receptor tyrosine kinase, c-ros oncogene 1 , receptor tyrosine kinase, proto-oncogene c-Ros-1, transmembrane tyrosine-specific protein kinase, v-ros avian UR2 sarcoma virus oncogene homolog 1
- Genomic Location:
- Chr 6: 117716223-117853711
- Description:
-
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
6q22.1
GO Molecular Function
transmembrane receptor protein tyrosine kinase activity | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein phosphatase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of ERK1 and ERK2 cascade | regulation of phosphate transport | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | negative regulation of cellular process | cell differentiation | male gamete generation | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | cellular process | negative regulation of signaling | multicellular organismal reproductive process | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | tissue development | gamete generation | peptidyl-tyrosine autophosphorylation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | response to stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | epithelial cell development | reproduction | negative regulation of metabolic process | protein modification process | macromolecule modification | regulation of TOR signaling | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | regulation of phosphorylation | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | cell proliferation | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | protein tyrosine kinase activity | multicellular organism reproduction | protein metabolic process | positive regulation of protein modification process | regulation of growth | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | negative regulation of programmed cell death | protein kinase activity | organic substance metabolic process | negative regulation of gene expression | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | positive regulation of MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | cell development | positive regulation of phosphorylation | cellular protein metabolic process | regulation of ion transport | kinase activity | developmental process | regulation of cell growth | spermatogenesis | cellular protein modification process | columnar/cuboidal epithelial cell development | regulation of transport | epithelial cell differentiation | regulation of anion transport | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | sexual reproduction | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | perinuclear region of cytoplasm | integral component of plasma membrane | cell periphery | cell surface | intracellular | membrane | intrinsic component of plasma membrane
