QuickView for ship (gene)

Gene Symbol:

INPP5D Homo sapiens

Full name:

inositol polyphosphate-5-phosphatase D

Synonyms:

SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, inositol polyphosphate-5-phosphatase, 145kD, inositol polyphosphate-5-phosphatase, 145kDa, signaling inositol polyphosphate 5 phosphatase SIP-145, signaling inositol polyphosphate phosphatase SHIP II

Genomic Location:

Chr 2: 233633280-233781288

Description:

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated b...

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This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCATTA_MIR155 ,  TAATAAT_MIR126

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-155

Cytogenetic Map:

2q37.1

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