QuickView for stem cell factor (gene)

Gene Symbol:

KITLG Homo sapiens

Full name:

KIT ligand

Synonyms:

DCUA, DFNA69, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, SLF, kit ligand, c-Kit ligand, familial progressive hyperpigmentation 2, mast cell growth factor, steel factor, stem cell factor

Genomic Location:

Chr 12: 87410697-87498369

Description:

This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hema...

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This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PBX1_02 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  HNF1_01 ,  TTANTCA_UNKNOWN ,  AAAGGGA_MIR204_MIR211 ,  ATTACAT_MIR3803P ,  GCAAGGA_MIR502 ,  AP2GAMMA_01 ,  FXR_IR1_Q6 ,  STAT6_01 ,  ACTTTAT_MIR1425P ,  CTTTGA_LEF1_Q2 ,  AP2ALPHA_01 ,  TATAAA_TATA_01 ,  FOXO3_01 ,  GGATTA_PITX2_Q2 ,  TATA_C ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  PITX2_Q2 ,  AAGGGAT_MIR188 ,  AATGTGA_MIR23A_MIR23B ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  AAAYRNCTG_UNKNOWN ,  CTGCAGY_UNKNOWN ,  TCCATTKW_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  AACTTT_UNKNOWN ,  TCF1P_Q6 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-188

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Cytogenetic Map:

12q21.32

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