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QuickView for stn1 (gene)


Gene Symbol:
STN1 Homo sapiens Homo sapiens
Full name:
STN1, CST complex subunit
Synonyms:
AAF-44, AAF44, OBFC1, RPA-32, bA541N10.2, CST complex subunit STN1, alpha accessory factor 44, oligonucleotide/oligosaccharide binding fold containing 1, oligonucleotide/oligosaccharide-binding fold-containing protein 1, replication protein A 32 kDa subunit, suppressor of cdc thirteen homolog
Genomic Location:
Chr 10: 105632290-105667956
Description:
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 6131...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 10
10q24.33


Transcripts Names
NM_024928
Protein Names
Q5TCZ0
Q9H668
D3DR99



GO Molecular Function

sequence-specific DNA binding | sequence-specific single stranded DNA binding | nucleic acid binding | single-stranded DNA binding | DNA binding | organic cyclic compound binding | protein binding | single-stranded telomeric DNA binding | heterocyclic compound binding | telomeric DNA binding

GO Biological Process

regulation of telomere maintenance via telomerase | positive regulation of macromolecule biosynthetic process | telomere maintenance | negative regulation of cellular process | telomere capping | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of DNA biosynthetic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | anatomical structure homeostasis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound metabolic process | telomere organization | negative regulation of metabolic process | telomere maintenance via telomere lengthening | nitrogen compound metabolic process | positive regulation of DNA replication | regulation of telomere maintenance | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of telomere maintenance via telomere lengthening | regulation of cellular metabolic process | homeostatic process | negative regulation of telomere maintenance | DNA metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of telomere maintenance via telomerase | regulation of chromosome organization | negative regulation of chromosome organization | negative regulation of telomere maintenance via telomere lengthening | positive regulation of DNA metabolic process | organelle organization | regulation of DNA biosynthetic process | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of cellular component organization | macromolecule metabolic process

GO Cellular Component

nuclear telomere cap complex | chromosome | intracellular membrane-bounded organelle | fibrillar center | cell | nuclear lumen | nucleolus | intracellular organelle | intermediate filament cytoskeleton | CST complex | protein-containing complex | protein-DNA complex | telomere cap complex | nucleoplasm | nuclear chromosome | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | nuclear chromosome, telomeric region | intracellular