QuickView for transthyretin (gene)

Gene Symbol:

Ttr Mus musculus

Full name:

transthyretin

Synonyms:

AA408768, AI787086, D17860, prealbumin, transthyretin

Genomic Location:

Chr 18: 20823914-20832820

Description:

This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, thi...

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This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CDP_01 ,  PBX1_01 ,  HNF3B_01 ,  TATA_01 ,  RFX1_02 ,  FREAC3_01 ,  CART1_01 ,  FOXO3_01 ,  HNF4ALPHA_Q6 ,  HNF6_Q6 ,  HNF4_DR1_Q3 ,  COUP_DR1_Q6 ,  FOX_Q2 ,  CAGTGTT_MIR141_MIR200A ,  TGCTGAY_UNKNOWN ,  TTANTCA_UNKNOWN ,  WCAANNNYCAG_UNKNOWN ,  YCATTAA_UNKNOWN ,  RGTTAMWNATT_HNF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-141

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