QuickView for type V collagen (gene)

Gene Symbol:

COL5A1 Homo sapiens

Full name:

collagen type V alpha 1 chain

Synonyms:

EDSC, EDSCL1, collagen alpha-1(V) chain, collagen, type V, alpha 1

Genomic Location:

Chr 9: 136673473-136876510

Description:

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. ...

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This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGA_LEF1_Q2 ,  GTGCCTT_MIR506

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

9q34.3

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