QuickView for tyrosyl-tRNA synthetase (gene)

Gene Symbol:

YARS Homo sapiens

Full name:

tyrosyl-tRNA synthetase

Synonyms:

CMTDIC, TYRRS, YRS, YTS, tyrosine--tRNA ligase, cytoplasmic, tyrosine tRNA ligase 1, cytoplasmic, tyrosyl--tRNA ligase, tyrosyl-tRNA synthetase, cytoplasmic

Genomic Location:

Chr 1: 33013427-33056220

Description:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase...

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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  GCGSCMNTTT_UNKNOWN ,  STAT4_01 ,  GATA1_01 ,  ZIC1_01 ,  RYTTCCTG_ETS2_B ,  MAZ_Q6 ,  AREB6_02 ,  YTATTTTNR_MEF2_02 ,  NFY_C ,  CTTTGA_LEF1_Q2 ,  PAX3_01 ,  TAAWWATAG_RSRFC4_Q2 ,  TCF4_Q5 ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  LEF1_Q2 ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTG_E12_Q6 ,  GR_Q6 ,  GGGCGGR_SP1_Q6 ,  AREB6_01 ,  PAX6_01 ,  MEIS1_01 ,  NF1_Q6_01 ,  GGCAGCT_MIR22 ,  CART1_01 ,  SCGGAAGY_ELK1_02 ,  ZIC2_01 ,  T3R_Q6 ,  TGACAGNY_MEIS1_01 ,  TAANNYSGCG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  KTGGYRSGAA_UNKNOWN ,  ACCTGTTG_UNKNOWN ,  PPARA_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-22

Cytogenetic Map:

1p35.1

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