UL16 protein (also known as cytoplasmic envelopment protein 2) plays a role in capsid maturation including DNA packaging/cleavage. In immunofluorescence studies, UL16 was localised to the nucleus of infected cells in areas containing high concentrations of Human herpesvirus 2 (Herpes simplex virus 2) capsid proteins. These nuclear compartments have been described previously as viral assemblons and are distinct from compartments containing replicating DNA. Localization within assemblons argues for a role of UL16 encoded protein in capsid assembly or maturation.UL94 is a human cytomegalovirus (HCMV) homologue that has been shown to be involved in facilitating secondary envelopment of virions.