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QuickView for vitronectin (gene)


Gene Symbol:
VTN Homo sapiens Homo sapiens
Full name:
vitronectin
Synonyms:
V75, VN, VNT, vitronectin, S-protein, complement S-protein, epibolin, serum spreading factor, somatomedin B
Genomic Location:
Chr 17: 23718425-23721500
Description:
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 17
17q11.2


Transcripts Names
NM_000638
Protein Names
P04004
P01141
Q9BSH7
B2R7G0
D9ZGG2



GO Molecular Function

structural molecule activity | protein-containing complex binding | signaling receptor binding | carbohydrate derivative binding | extracellular matrix binding | anion binding | collagen binding | identical protein binding | ion binding | integrin binding | heparin binding | cell adhesion molecule binding | carbohydrate binding | protein binding | scavenger receptor activity | glycosaminoglycan binding | cargo receptor activity | extracellular matrix structural constituent | polysaccharide binding

GO Biological Process

positive regulation of locomotion | extracellular structure organization | positive regulation of cellular component organization | cell motility | regulation of localization | cell-substrate adhesion | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | regulation of immune system process | negative regulation of cellular process | cell differentiation | nervous system development | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | negative regulation of proteolysis | positive regulation of vascular endothelial growth factor receptor signaling pathway | cellular process | regulation of cell motility | localization | regulation of vascular endothelial growth factor receptor signaling pathway | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of binding | regeneration | negative regulation of wound healing | regulation of immune response | regulation of cellular process | regulation of metabolic process | gliogenesis | hepaticobiliary system development | positive regulation of cellular protein metabolic process | cellular component organization | positive regulation of protein binding | smooth muscle cell-matrix adhesion | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | cell adhesion mediated by integrin | regulation of smooth muscle cell migration | regulation of humoral immune response | extracellular matrix organization | negative regulation of metabolic process | cellular component assembly | regulation of wound healing | regulation of protein processing | regulation of cell adhesion | embryo development | locomotion | system development | positive regulation of response to wounding | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of peptidase activity | positive regulation of smooth muscle cell migration | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | regulation of acute inflammatory response | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | liver development | regulation of blood coagulation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | protein polymerization | vesicle-mediated transport | regulation of cellular component movement | endoderm formation | positive regulation of cell migration | cell proliferation | regulation of cellular protein metabolic process | glial cell differentiation | cellular protein-containing complex assembly | regulation of complement activation | negative regulation of response to wounding | regulation of cellular metabolic process | liver regeneration | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | positive regulation of molecular function | scavenger receptor activity | protein-containing complex assembly | positive regulation of protein modification process | gland development | import into cell | anatomical structure development | regulation of body fluid levels | oligodendrocyte differentiation | regulation of vesicle-mediated transport | endocytosis | cell adhesion | immune response | animal organ development | positive regulation of cell-substrate adhesion | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | positive regulation of wound healing | positive regulation of binding | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | cell-matrix adhesion | regulation of protein binding | regulation of endocytosis | positive regulation of phosphorylation | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | regulation of endopeptidase activity | receptor-mediated endocytosis | developmental process | negative regulation of coagulation | regulation of transport | formation of primary germ layer | negative regulation of hydrolase activity | central nervous system development | negative regulation of blood coagulation | positive regulation of metabolic process | cargo receptor activity | gastrulation | immune system process | positive regulation of cell motility | regulation of inflammatory response | positive regulation of endocytosis | regulation of cellular component organization | positive regulation of signaling | regulation of signaling | negative regulation of endopeptidase activity | animal organ regeneration | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | extracellular matrix | basement membrane | cell | plasma membrane protein complex | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | endoplasmic reticulum | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | vesicle | endoplasmic reticulum lumen | extracellular exosome | rough endoplasmic reticulum lumen | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane-enclosed lumen | alphav-beta3 integrin-vitronectin complex | blood microparticle | rough endoplasmic reticulum | intracellular | membrane | Golgi lumen