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QuickView for xanthine oxidase (gene)


Gene Symbol:
Xdh Mus musculus Mus musculus
Full name:
xanthine dehydrogenase
Synonyms:
XO, Xor, Xox-1, Xox1, xanthine dehydrogenase/oxidase, xanthine oxidase, xanthine oxidoreductase
Genomic Location:
Chr 17: 74233248-74299522
Description:
This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine d...
Orthologs:
Homo sapiens Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_011723
XM_011246381
Protein Names
E9QLM9
Q9CVF2
Q00519



GO Molecular Function

cofactor binding | cation binding | nucleotide binding | flavin adenine dinucleotide binding | iron ion binding | coenzyme binding | molybdenum ion binding | nitrite reductase (NO-forming) activity | catalytic activity | anion binding | electron transfer activity | iron-sulfur cluster binding | molybdopterin cofactor binding | nitrite reductase activity | identical protein binding | xanthine dehydrogenase activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | FAD binding | protein dimerization activity | oxidoreductase activity, acting on other nitrogenous compounds as donors | 2 iron, 2 sulfur cluster binding | xanthine oxidase activity | transition metal ion binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

negative regulation of phosphorylation | regulation of cysteine-type endopeptidase activity | negative regulation of vasculogenesis | positive regulation of apoptotic process | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | response to metal ion | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | cellular process | secretion | organic substance catabolic process | localization | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | regulation of vascular endothelial growth factor signaling pathway | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | nitrite reductase (NO-forming) activity | regulation of cell proliferation | electron transport chain | positive regulation of cysteine-type endopeptidase activity | regulation of epithelial cell differentiation | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | regulation of cellular response to stress | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | regulation of peptidase activity | regulation of MAPK cascade | mammary gland development | regulation of catalytic activity | regulation of phosphorylation | electron transfer activity | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of p38MAPK cascade | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | nitrite reductase activity | positive regulation of hydrolase activity | nucleobase-containing small molecule metabolic process | negative regulation of protein kinase B signaling | xanthine dehydrogenase activity | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | negative regulation of cellular response to vascular endothelial growth factor stimulus | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of endothelial cell differentiation | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | hypoxanthine oxidation | regulation of protein phosphorylation | regulation of cellular response to growth factor stimulus | negative regulation of epithelial cell differentiation | positive regulation of molecular function | negative regulation of epithelial cell proliferation | positive regulation of protein modification process | gland development | lactation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of body fluid levels | oxidation-reduction process | oxidoreductase activity, acting on other nitrogenous compounds as donors | nucleobase catabolic process | negative regulation of endothelial cell proliferation | positive regulation of cell death | body fluid secretion | purine nucleobase catabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | xanthine oxidase activity | negative regulation of gene expression | animal organ development | regulation of endothelial cell proliferation | negative regulation of vascular endothelial growth factor signaling pathway | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | hypoxanthine metabolic process | regulation of phosphate metabolic process | regulation of vasculogenesis | positive regulation of MAPK cascade | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | xanthine catabolic process | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of endopeptidase activity | regulation of developmental process | developmental process | purine nucleobase metabolic process | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | negative regulation of vasculature development | regulation of endothelial cell differentiation | heterocycle metabolic process | response to aluminum ion | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | oxidoreductase activity | negative regulation of cell differentiation | positive regulation of signaling | regulation of signaling | regulation of p38MAPK cascade | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

sarcoplasmic reticulum | intracellular membrane-bounded organelle | peroxisome | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | extracellular region | membrane-bounded organelle | organelle | sarcoplasm | extracellular space | cytosol | intracellular