QuickView for ACSL1;jsessionid=6784E397FD4140E8640479C4C1CADB64;jsessionid=1EE1C50DF9C07E417C27BE5459BFAD3B;jsessionid=F72EE32390C156142FB702ACF0945DBF (gene)

Gene Symbol:

Acsl1 Mus musculus

Full name:

acyl-CoA synthetase long-chain family member 1

Synonyms:

Acas, Acas1, Acs, FACS, Facl2, LACS 1, LACS1, long-chain-fatty-acid--CoA ligase 1, acetate-CoA ligase, acetyl-CoA synthetase, acetyl-Coenzyme A synthetase 1 (ADP forming), fatty acid Coenzyme A ligase, long chain 2, long-chain acyl-CoA synthetase 1

Genomic Location:

Chr 8: 47556396-47621404

Description:

The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is ex...

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The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ATGAAGG_MIR205 ,  AAGCACA_MIR218 ,  TGCCTTA_MIR124A ,  ACTGCCT_MIR34B ,  CAGTCAC_MIR134 ,  RTAAACA_FREAC2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-543

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