QuickView for ADRA1A;jsessionid=23DBC257C0F2E82CBD54A591DA2DAC41;jsessionid=D527B391B6FE66C97FD1895433A57E44 (gene)
- Gene Symbol:
- Adra1a
Mus musculus - Full name:
- adrenergic receptor, alpha 1a
- Synonyms:
- Adra1c, alpha-1A adrenergic receptor, alpha-1A adrenoceptor, alpha-1A adrenoreceptor, alpha-1C adrenergic receptor
- Genomic Location:
- Chr 14: 67254095-67352166
- Description:
-
This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this g...
- Orthologs:
- Homo sapiens , Rattus norvegicus , C. elegans , Macaca mulatta , Bos taurus , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , NFE2_01 , COUP_01 , AP1_C , MEF2_02 , CHX10_01 , CTCNANGTGNY_UNKNOWN , BACH2_01 , BACH1_01 , AP1_01
GO Molecular Function
alpha-adrenergic receptor activity | transmembrane signaling receptor activity | G-protein coupled receptor activity | G-protein coupled amine receptor activity | adrenergic receptor activity | signaling receptor activity | protein heterodimerization activity | protein binding | protein dimerization activity | alpha1-adrenergic receptor activity
GO Biological Process
positive regulation of heart contraction | regulation of ERK1 and ERK2 cascade | positive regulation of action potential | regulation of blood vessel diameter | regulation of muscle system process | reflex | positive regulation of blood circulation | muscle tissue development | intracellular signal transduction | cytosolic calcium ion transport | regulation of the force of heart contraction by chemical signal | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | regulation of autophagy | response to hormone | cell growth involved in cardiac muscle cell development | negative regulation of cellular process | cell differentiation | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | striated muscle cell development | regulation of smooth muscle contraction | response to drug | organ growth | cellular chemical homeostasis | positive regulation of phosphate metabolic process | negative regulation of heart rate | cardiac cell development | cellular process | localization | cellular homeostasis | pilomotor reflex | positive regulation of synaptic transmission | positive regulation of non-membrane spanning protein tyrosine kinase activity | negative regulation of signaling | metal ion transport | developmental growth | positive regulation of protein kinase activity | alpha-adrenergic receptor activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | activation of phospholipase C activity | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | positive regulation of cardiac muscle hypertrophy | muscle structure development | muscle cell differentiation | positive regulation of vasoconstriction | regulation of cellular process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | neurological system process involved in regulation of systemic arterial blood pressure | positive regulation of cellular protein metabolic process | regulation of systemic arterial blood pressure mediated by a chemical signal | calcium ion homeostasis | G-protein coupled receptor activity | calcium ion transport into cytosol | response to stimulus | positive regulation of blood pressure | muscle cell development | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | positive regulation of protein kinase C signaling | regulation of blood vessel size | adenylate cyclase-activating adrenergic receptor signaling pathway | regulation of blood circulation | cardiac muscle tissue development | G-protein coupled amine receptor activity | physiological cardiac muscle hypertrophy | regulation of heart rate | cellular localization | divalent metal ion transport | positive regulation of lipase activity | positive regulation of the force of heart contraction by chemical signal | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of systemic arterial blood pressure by baroreceptor feedback | modulation of chemical synaptic transmission | heart growth | metal ion homeostasis | negative regulation of blood pressure | negative regulation of blood vessel diameter | regulation of membrane potential | positive regulation of phospholipase C activity | regulation of protein tyrosine kinase activity | system development | adrenergic receptor activity | regulation of signal transduction | multicellular organism development | regulation of synaptic transmission, GABAergic | regulation of MAPK cascade | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of muscle contraction | regulation of catalytic activity | regulation of phosphorylation | regulation of small GTPase mediated signal transduction | nervous system process | regulation of blood pressure | excretion | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | cardiocyte differentiation | regulation of the force of heart contraction | positive regulation of hydrolase activity | second-messenger-mediated signaling | regulation of Rho protein signal transduction | cardiac muscle hypertrophy | regulation of cellular protein metabolic process | cardiac muscle cell development | vasoconstriction | regulation of phospholipase activity | norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure | regulation of heart contraction | cation homeostasis | negative regulation of autophagy | regulation of striated muscle contraction | striated muscle tissue development | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of smooth muscle contraction | cyclic-nucleotide-mediated signaling | regulation of cardiac muscle contraction | regulation of protein kinase C signaling | regulation of protein metabolic process | positive regulation of signal transduction | heart development | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | positive regulation of synaptic transmission, GABAergic | regulation of tube size | positive regulation of the force of heart contraction by epinephrine-norepinephrine | negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure | striated muscle cell differentiation | positive regulation of systemic arterial blood pressure | cardiac muscle tissue growth | regulation of phospholipase C activity | positive regulation of molecular function | positive regulation of heart rate | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | response to organic substance | cAMP-mediated signaling | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | positive regulation of cardiac muscle contraction | regulation of vasoconstriction | regulation of tube diameter | positive regulation of striated muscle contraction | negative regulation of heart contraction | chemical homeostasis | calcium ion transport | negative regulation of Rho protein signal transduction | positive regulation of muscle contraction | animal organ development | negative regulation of small GTPase mediated signal transduction | negative regulation of Ras protein signal transduction | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | micturition | ion homeostasis | regulation of phosphate metabolic process | phospholipase C-activating G-protein coupled receptor signaling pathway | renal system process | positive regulation of phospholipase activity | positive regulation of MAPK cascade | alpha1-adrenergic receptor activity | regulation of action potential | cardiac muscle cell differentiation | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of signal transduction | signaling | negative regulation of systemic arterial blood pressure | cell development | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | regulation of Ras protein signal transduction | cation transport | developmental process | positive regulation of heart rate by epinephrine-norepinephrine | adrenergic receptor signaling pathway | developmental cell growth | cellular metal ion homeostasis | positive regulation of metabolic process | ion transport | adult heart development | circulatory system development | aging | muscle hypertrophy | divalent inorganic cation homeostasis | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | integral component of membrane | intracellular membrane-bounded organelle | sarcolemma | organelle membrane | sarcomere | nuclear membrane | cell | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | contractile fiber | endomembrane system | plasma membrane | nuclear envelope | integral component of plasma membrane | T-tubule | membrane-bounded organelle | nucleus | organelle | I band | cell periphery | Z disc | intracellular | membrane | supramolecular complex | intrinsic component of plasma membrane
