QuickView for AGO1;jsessionid=7E2F3F547E520AA5324A79A9E7005B90;jsessionid=68C83FC5306E0EA9D38389EAE2489223;jsessionid=A93195D422B3C63B52E9C75BC5640E18 (gene)

Gene Symbol:

Ago1 Rattus norvegicus

Full name:

argonaute 1, RISC catalytic component

Synonyms:

Eif2c1, protein argonaute-1, argonaute RISC catalytic component 1, eukaryotic translation initiation factor 2C, 1

Genomic Location:

Chr 5: 145794769-145830979

Description:

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional g...

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This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to a C-terminally extended isoform by use of an alternative in-frame translation termination codon.

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Orthologs:

Homo sapiens ,  Mus musculus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_01 ,  E47_01 ,  HEN1_01 ,  MZF1_01 ,  MYOD_Q6 ,  AML1_01 ,  TITF1_Q3 ,  CTCNANGTGNY_UNKNOWN ,  CTGCAGY_UNKNOWN ,  EFC_Q6 ,  E12_Q6 ,  ETF_Q6 ,  TEF1_Q6 ,  MYOGENIN_Q6 ,  OSF2_Q6 ,  LEF1_Q6 ,  AML1_Q6 ,  E2F_Q2 ,  EGR_Q6 ,  MYOD_Q6_01 ,  SP1_Q2_01 ,  VDR_Q6 ,  T3R_Q6 ,  HNF4_Q6 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCACTG_MIR148A_MIR152_MIR148B ,  GGGYGTGNY_UNKNOWN ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ACATTCC_MIR1_MIR206 ,  AAGTCCA_MIR422B_MIR422A ,  TTTGCAC_MIR19A_MIR19B ,  AAGCCAT_MIR135A_MIR135B ,  ATGCTGC_MIR103_MIR107 ,  GTGGGTGK_UNKNOWN ,  GTGCCTT_MIR506 ,  ACACTCC_MIR122A ,  CTATGCA_MIR153 ,  GTCTTCC_MIR7 ,  AGGCACT_MIR5153P ,  TTGCCAA_MIR182 ,  GAGCCTG_MIR484 ,  AGGAAGC_MIR5163P ,  GGCAGCT_MIR22 ,  MYAATNNNNNNNGGC_UNKNOWN ,  TCTCTCC_MIR185 ,  CTGTTAC_MIR194 ,  CTCCAAG_MIR432 ,  TTTGTAG_MIR520D ,  AAAGACA_MIR511 ,  ACAACCT_MIR453 ,  GGCACTT_MIR519E ,  ATGTACA_MIR493 ,  GCATTTG_MIR105 ,  TCCAGAG_MIR518C ,  CACCAGC_MIR138 ,  GGTAACC_MIR4095P ,  TGCGCANK_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN ,  RACCACAR_AML_Q6 ,  CAGGTG_E12_Q6 ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  GGGTGGRR_PAX4_03 ,  GGGCGGR_SP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-325 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-544

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