QuickView for AKAP10;jsessionid=1ED081BC60B67C025421956F6FACE506;jsessionid=63759124AE5240F9AA6A2A1115D68111 (gene)

Gene Symbol:

Akap10 Mus musculus

Full name:

A kinase (PRKA) anchor protein 10

Synonyms:

1500031L16Rik, B130049N18Rik, D-AKAP-2, D-AKAP2, PRKA10, A-kinase anchor protein 10, mitochondrial, dual specificity A kinase-anchoring protein 2, protein kinase A-anchoring protein 10

Genomic Location:

Chr 11: 61684809-61743728

Description:

This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is importa...

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This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NMYC_01 ,  USF_01 ,  USF_Q6 ,  ARNT_01 ,  EGR2_01 ,  FOXO4_01 ,  GGGACCA_MIR133A_MIR133B ,  RNGTGGGC_UNKNOWN ,  TAANNYSGCG_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-155

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