QuickView for ALG8;jsessionid=08BCA638BB1D352BEBE1186695B51160;jsessionid=9DED28A0C5D4BF62ABFA9579BF6910D9;jsessionid=71A7B04357DF9DADA8EB979EB5D9F2F2;jsessionid=23B87EBB4ED407B88729D76910680BB7 (gene)

Gene Symbol:

ALG8 Homo sapiens

Full name:

ALG8, alpha-1,3-glucosyltransferase

Synonyms:

CDG1H, probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, HUSSY-02, asparagine-linked glycosylation 8 alpha-13-glucosyltransferase-like protein, asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase), asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase), asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog, asparagine-linked glycosylation protein 8 homolog, dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, dolichyl-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase, dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase, dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl-alpha-1,3-glucosyltransferase

Genomic Location:

Chr 11: 77489636-77528347

Description:

This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively s...

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This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GCAAGAC_MIR431 ,  CTCTGGA_MIR520A_MIR525 ,  NRF1_Q6

Cytogenetic Map:

11q14.1

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