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QuickView for ANGPT2;jsessionid=7D1D703D6C2B949600F429147F686899;jsessionid=34638CDC519ED92E5FBB539D63250B9A;jsessionid=1DF864BC7727AFBF67ED8200A50C63AD (gene)


Gene Symbol:
Angpt2 Mus musculus Mus musculus
Full name:
angiopoietin 2
Synonyms:
Agpt2, Ang-2, Ang2, angiopoietin-2
Genomic Location:
Chr 8: 18691337-18741551
Description:
This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs.
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_007426
Protein Names
Q3U1A1
O35608
B9EHQ4
Q9D2D2



GO Molecular Function

kinase binding | cation binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | signaling receptor binding | cytokine receptor binding | vascular endothelial growth factor receptor binding | ion binding | protein tyrosine kinase binding | protein binding | growth factor receptor binding | metal ion binding

GO Biological Process

regulation of localization | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | glomerulus development | blood vessel morphogenesis | cellular process | regulation of cell motility | tissue remodeling | immune system development | regulation of chemotaxis | negative regulation of cell migration | tissue development | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | negative regulation of chemotaxis | negative regulation of positive chemotaxis | urogenital system development | regulation of vasculature development | response to stimulus | vasculature development | blood vessel remodeling | negative regulation of cell adhesion | negative regulation of angiogenesis | tube morphogenesis | cardiovascular system development | hemopoiesis | regulation of cell adhesion | kidney development | blood vessel development | system development | multicellular organism development | glomerulus vasculature development | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | regulation of cellular component movement | regulation of endothelial cell migration | negative regulation of epithelial cell migration | negative regulation of cell-substrate adhesion | Tie signaling pathway | angiogenesis | negative regulation of blood vessel endothelial cell migration | cell communication | regulation of locomotion | renal system development | nephron development | anatomical structure development | cell surface receptor signaling pathway | animal organ development | negative regulation of cellular component movement | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of blood vessel endothelial cell migration | signaling | endoderm development | anatomical structure morphogenesis | regulation of developmental process | developmental process | tube development | negative regulation of vasculature development | negative regulation of endothelial cell migration | transmembrane receptor protein tyrosine kinase signaling pathway | immune system process | hematopoietic or lymphoid organ development | circulatory system development | negative regulation of locomotion | positive regulation of angiogenesis | signal transduction | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | intracellular organelle | cell projection | plasma membrane | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | intracellular | membrane