QuickView for ATM-1;jsessionid=4AEC8BC1C870EA18D74A1791525EC8E6;jsessionid=8D927B923F7541B45754AE9E06EE4F60;jsessionid=33751D7B556F640298EFCBDA81B32E26 (gene)
- Gene Symbol:
- Atm
Mus musculus - Full name:
- ataxia telangiectasia mutated
- Synonyms:
- AI256621, C030026E19Rik, serine-protein kinase ATM, A-T mutated homolog, ataxia telangiectasia gene mutated in human beings, ataxia telangiectasia mutated homolog
- Genomic Location:
- Chr 9: 53247473-53344678
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
nucleic acid binding | protein-containing complex binding | ribonucleotide binding | DNA-dependent protein kinase activity | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | protein N-terminus binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | phosphatidylinositol 3-kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | 1-phosphatidylinositol-3-kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | negative regulation of leukocyte activation | negative regulation of TOR signaling | regulation of telomere maintenance via telomerase | brain development | double-strand break repair | response to radiation | cellular response to X-ray | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | negative regulation of immune system process | positive regulation of cellular component organization | regulation of B cell activation | developmental process involved in reproduction | intracellular signal transduction | ovarian follicle development | positive regulation of apoptotic process | gonad development | regulation of programmed cell death | female gonad development | peptidyl-amino acid modification | response to X-ray | phosphatidylinositol metabolic process | establishment of localization | regulation of autophagy | regulation of immune system process | neuron death | negative regulation of cellular process | signal transduction involved in mitotic G2 DNA damage checkpoint | histone modification | cell differentiation | male gamete generation | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of B cell proliferation | multicellular organism growth | male meiotic nuclear division | positive regulation of phosphate metabolic process | regulation of organelle organization | phosphatidylinositol-3-phosphate biosynthetic process | B cell differentiation | phospholipid metabolic process | negative regulation of DNA metabolic process | pattern specification process | regulation of neuron death | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of signal transduction by p53 class mediator | organic substance catabolic process | histone mRNA catabolic process | lymphocyte differentiation | establishment of organelle localization | localization | chromatin organization | mitotic DNA integrity checkpoint | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | developmental growth | reproductive system development | regulation of mitotic nuclear division | immune system development | lipoprotein catabolic process | multicellular organismal reproductive process | regulation of chromosome separation | macromolecule localization | regulation of histone modification | negative regulation of chromosome segregation | response to hypoxia | regulation of cell cycle | regulation of cellular response to gamma radiation | positive regulation of nitrogen compound metabolic process | cellular response to nitrosative stress | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | gamete generation | negative regulation of mitotic metaphase/anaphase transition | anatomical structure homeostasis | intrinsic apoptotic signaling pathway | DNA damage induced protein phosphorylation | spindle checkpoint | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organelle localization | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | meiotic telomere clustering | pre-B cell differentiation | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | establishment of chromosome localization | DNA-dependent protein kinase activity | mRNA catabolic process | development of primary sexual characteristics | head development | regulation of telomere capping | response to stimulus | thymus development | female gamete generation | regulation of mitotic cell cycle phase transition | chromosome segregation | histone mRNA metabolic process | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | negative regulation of lymphocyte activation | germ cell development | regulation of cell proliferation | mitotic G2 DNA damage checkpoint | regulation of cell cycle phase transition | protein serine/threonine kinase activity | programmed cell death | development of primary female sexual characteristics | reproduction | cellular localization | positive regulation of telomerase catalytic core complex assembly | cellular nitrogen compound metabolic process | telomere organization | negative regulation of metabolic process | hemopoiesis | protein modification process | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | cellular biosynthetic process | embryo development | DNA recombination | macromolecule modification | nucleobase-containing compound catabolic process | regulation of TOR signaling | positive regulation of telomere maintenance via telomere lengthening | meiotic chromosome segregation | DNA repair | anterior/posterior pattern specification | leukocyte differentiation | regulation of cellular response to stress | apoptotic process | positive regulation of DNA catabolic process | regulation of cell cycle G2/M phase transition | regulation of histone phosphorylation | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | double-strand break repair via homologous recombination | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of cell cycle G2/M phase transition | telomere localization | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of telomere maintenance | lipid metabolic process | oocyte differentiation | regulation of phosphorylation | positive regulation of DNA damage response, signal transduction by p53 class mediator | response to nitrosative stress | positive regulation of chromosome organization | signal transduction in response to DNA damage | regulation of gene expression | regulation of TORC1 signaling | cellular response to stress | cell cycle | protein catabolic process | RNA catabolic process | organophosphate metabolic process | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular response to radiation | phospholipid biosynthetic process | protein autophosphorylation | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | neuron apoptotic process | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | phosphatidylinositol 3-kinase activity | cellular response to gamma radiation | oogenesis | negative regulation of mitotic nuclear division | B cell activation | V(D)J recombination | biosynthetic process | regulation of cellular protein metabolic process | phosphorylation | lipid biosynthetic process | positive regulation of neuron death | establishment of RNA localization | positive regulation of telomere maintenance via telomerase | signal transduction involved in cell cycle checkpoint | mitotic spindle assembly checkpoint | protein phosphorylation | response to gamma radiation | post-embryonic development | immature B cell differentiation | phosphate-containing compound metabolic process | regulation of macrophage activation | lipid phosphorylation | nuclear chromosome segregation | regulation of telomere maintenance via telomere lengthening | chordate embryonic development | cell communication | regulation of cellular metabolic process | negative regulation of mitotic sister chromatid segregation | regulation of neuron apoptotic process | lipoprotein metabolic process | positive regulation of DNA biosynthetic process | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | heart development | lipid modification | chromosome localization to nuclear envelope involved in homologous chromosome segregation | homeostatic process | negative regulation of mitotic sister chromatid separation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | glycerolipid metabolic process | histone phosphorylation | negative regulation of telomere maintenance | apoptotic signaling pathway | cell aging | negative regulation of B cell activation | regulation of mitotic cell cycle | lymphocyte activation | pre-B cell allelic exclusion | mitotic G2/M transition checkpoint | multicellular organism reproduction | homologous chromosome segregation | protein metabolic process | regionalization | positive regulation of protein modification process | gland development | glycerophospholipid biosynthetic process | 1-phosphatidylinositol-3-kinase activity | cell cycle arrest | DNA metabolic process | replicative senescence | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | regulation of sister chromatid segregation | positive regulation of neuron apoptotic process | peptidyl-serine autophosphorylation | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | immunoglobulin production | negative regulation of leukocyte proliferation | negative regulation of mitotic cell cycle | positive regulation of cell death | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | signal transduction involved in G2 DNA damage checkpoint | protein kinase activity | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of gene expression | animal organ development | positive regulation of histone modification | regulation of cell activation | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | cellular response to ionizing radiation | regulation of phosphate metabolic process | regulation of chromosome organization | phosphatidylinositol biosynthetic process | chromosome organization involved in meiotic cell cycle | negative regulation of TORC1 signaling | meiosis I | cell activation | oocyte development | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of mitotic sister chromatid segregation | meiotic cell cycle | multicellular organism aging | regulation of cell communication | negative regulation of chromosome organization | negative regulation of signal transduction | signaling | somite development | covalent chromatin modification | cell development | determination of adult lifespan | positive regulation of phosphorylation | cellular protein metabolic process | phosphatidylinositol phosphorylation | anatomical structure morphogenesis | somatic cell DNA recombination | signal transduction involved in DNA damage checkpoint | reproductive structure development | glycerophospholipid metabolic process | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | kinase activity | segmentation | negative regulation of telomere capping | recombinational repair | developmental process | organelle organization | regulation of DNA biosynthetic process | peptidyl-serine phosphorylation | cellular protein modification process | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of mitotic metaphase/anaphase transition | heterocycle metabolic process | somitogenesis | central nervous system development | positive regulation of metabolic process | chromosome organization | negative regulation of lymphocyte proliferation | regulation of microglial cell activation | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | female sex differentiation | regulation of cell death | sex differentiation | DNA damage checkpoint | cell cycle checkpoint | positive regulation of histone phosphorylation | circulatory system development | aging | RNA localization | sexual reproduction | regulation of cellular component organization | response to ionizing radiation | establishment of RNA localization to telomere | positive regulation of signaling | signal transduction | regulation of signaling | female meiotic nuclear division | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | cytoplasmic vesicle | DNA repair complex | cell | nuclear lumen | nucleolus | cytoplasm | spindle | intracellular organelle | protein-containing complex | vesicle | microtubule cytoskeleton | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular vesicle | cytoskeleton | intracellular
