QuickView for BRG1;jsessionid=47B257CB53843B6B0211E8A1FACD0394;jsessionid=DFE54D8F04A604516E11D9E7C5F76FFC (gene)

Gene Symbol:

SMARCA4 Homo sapiens

Full name:

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Synonyms:

BAF190, BAF190A, BRG1, CSS4, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, transcription activator BRG1, ATP-dependent helicase SMARCA4, BRG1-associated factor 190A, BRM/SWI2-related gene 1, SNF2-beta, SNF2-like 4, brahma protein-like 1, global transcription activator homologous sequence, homeotic gene regulator, mitotic growth and transcription activator, nuclear protein GRB1, protein BRG-1, protein brahma homolog 1, sucrose nonfermenting-like 4

Genomic Location:

Chr 19: 10932606-11033953

Description:

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-...

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The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACTGTAG_MIR139 ,  GGGAGGRR_MAZ_Q6 ,  AGCATTA_MIR155 ,  ACATTCC_MIR1_MIR206 ,  YYCATTCAWW_UNKNOWN ,  TGCGCANK_UNKNOWN ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-155

Cytogenetic Map:

19p13.2

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