QuickView for Bcl-xL;jsessionid=B6EF7C754998C4B3CBD599C16A6E66E0;jsessionid=8B8749107084A24ABCAE7917A2EF5D54 (gene)
- Gene Symbol:
- Bcl2l1
Rattus norvegicus - Full name:
- Bcl2-like 1
- Synonyms:
- Bcl-xl, Bcl2l, Bclx, bcl-X, bcl-2-like protein 1, B cell lymphoma 2 like, B cell lymphoma like X, apoptosis regulator Bcl-X, bcl2-L-1
- Genomic Location:
- Chr 3: 143129087-143180199
- Description:
-
inhibits neuronal apoptosis; may provide neuroprotection against ischemic brian injury
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AAAYRNCTG_UNKNOWN , MYOD_01 , ELK1_01 , ELK1_02 , CETS1P54_01 , P300_01 , YY1_02 , E47_02 , GATA3_01 , NRF2_01
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
endopeptidase inhibitor activity | kinase binding | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | GTPase binding | clathrin binding | protein kinase binding | enzyme binding | protein-containing complex binding | enzyme inhibitor activity | molecular function regulator | protein domain specific binding | MDM2/MDM4 family protein binding | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | death domain binding | transcription factor binding | BH3 domain binding | protein dimerization activity | cysteine-type endopeptidase regulator activity involved in apoptotic process | peptidase inhibitor activity | enzyme regulator activity | BH domain binding | cysteine-type endopeptidase inhibitor activity
GO Biological Process
brain development | response to radiation | negative regulation of execution phase of apoptosis | regulation of cell cycle process | cellular response to decreased oxygen levels | regulation of cysteine-type endopeptidase activity | response to virus | endopeptidase inhibitor activity | release of cytochrome c from mitochondria | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | positive regulation of ATP metabolic process | intracellular signal transduction | ovarian follicle development | positive regulation of apoptotic process | regulation of localization | gonad development | regulation of programmed cell death | female gonad development | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | response to cycloheximide | negative regulation of cysteine-type endopeptidase activity | epithelial cell apoptotic process | establishment of localization | response to hormone | neuron death | negative regulation of neuron death | cellular response to prolactin | negative regulation of cellular process | positive regulation of neurotransmitter secretion | response to dexamethasone | response to metal ion | cellular response to tumor necrosis factor | regulation of protein localization to membrane | cell differentiation | male gamete generation | response to erythropoietin | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of mitochondrion organization | response to drug | cell part morphogenesis | cellular response to thapsigargin | positive regulation of phosphate metabolic process | regulation of organelle organization | membrane organization | response to antibiotic | intracellular transport | negative regulation of proteolysis | regulation of neuron death | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | establishment of organelle localization | localization | extrinsic apoptotic signaling pathway | positive regulation of synaptic transmission | regulation of mitochondrial membrane potential | negative regulation of signaling | negative regulation of protein localization to plasma membrane | reproductive system development | negative regulation of anoikis | multicellular organismal reproductive process | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | response to peptide hormone | gamete generation | interspecies interaction between organisms | intrinsic apoptotic signaling pathway | negative regulation of apoptotic signaling pathway | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | organelle localization | cellular response to organonitrogen compound | cellular component organization | regulation of cell division | development of primary sexual characteristics | head development | mitochondrion morphogenesis | response to stimulus | enzyme inhibitor activity | regulation of cellular protein localization | modulation by virus of host process | cellular response to xenobiotic stimulus | cellular response to hypoxia | positive regulation of synaptic vesicle recycling | response to stress | germ cell development | regulation of cell proliferation | positive regulation of synaptic vesicle exocytosis | response to peptide | programmed cell death | development of primary female sexual characteristics | reproduction | cellular localization | response to alcohol | response to molecule of bacterial origin | response to ischemia | apoptotic mitochondrial changes | cellular response to organic cyclic compound | negative regulation of metabolic process | regulation of anoikis | modulation of chemical synaptic transmission | embryo development | mitochondrion organization | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | regulation of intracellular transport | molecular function regulator | apoptotic process in bone marrow | regulation of membrane potential | positive regulation of exocytosis | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | negative regulation of neuron apoptotic process | apoptotic process | cellular response to hormone stimulus | synaptic vesicle cycle | response to external biotic stimulus | system development | response to oxygen levels | reproductive process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of synaptic vesicle exocytosis | response to amino acid | response to purine-containing compound | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of intrinsic apoptotic signaling pathway | negative regulation of cellular protein localization | negative regulation of peptidase activity | synaptic vesicle recycling | telencephalon development | cellular process regulating host cell cycle in response to virus | regulation of extrinsic apoptotic signaling pathway | positive regulation of secretion | regulation of mitochondrial membrane permeability | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | cell cycle | suppression by virus of host apoptotic process | modification of morphology or physiology of other organism | synaptic vesicle recycling via endosome | positive regulation of cellular metabolic process | cellular response to radiation | mitochondrial transport | cellular response to oxygen levels | positive regulation of ATP biosynthetic process | response to astaxanthin | regulation of nitrogen compound metabolic process | neuron apoptotic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | response to corticosteroid | vesicle-mediated transport | cellular response to alkaloid | cellular response to gamma radiation | response to oxidative stress | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of extrinsic apoptotic signaling pathway | cellular response to cytokine stimulus | establishment of vesicle localization | cell proliferation | regulation of cellular protein metabolic process | cellular response to glucocorticoid stimulus | fertilization | hepatocyte apoptotic process | regulation of synaptic vesicle clustering | regulation of synaptic vesicle endocytosis | regulation of synaptic vesicle transport | response to toxic substance | regulation of apoptotic signaling pathway | response to xenobiotic stimulus | cellular response to amino acid stimulus | response to gamma radiation | cellular response to corticosteroid stimulus | positive regulation of regulated secretory pathway | cellular response to drug | regulation of mitochondrion organization | response to bacterium | mitochondrial membrane organization | chordate embryonic development | regulation of long term synaptic depression | cell communication | regulation of cellular metabolic process | regulation of cytokinesis | regulation of neuron apoptotic process | regulation of protein metabolic process | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | positive regulation of transport | viral process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | cerebral cortex development | cellular response to virus | apoptotic signaling pathway | regulation of mitotic cell cycle | cellular response to astaxanthin | multicellular organism reproduction | development of primary male sexual characteristics | regulation of growth | response to organic substance | male sex differentiation | response to antineoplastic agent | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of exocytosis | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | positive regulation of calcium ion-dependent exocytosis | regulation of protein localization to plasma membrane | negative regulation of programmed cell death | male gonad development | response to prolactin | negative regulation of mitotic cell cycle | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | positive regulation of cell death | regulation of response to DNA damage stimulus | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | cell death | animal organ development | response to reactive oxygen species | forebrain development | pallium development | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | cellular response to ionizing radiation | cellular response to cAMP | regulation of ATP metabolic process | regulation of phosphate metabolic process | response to anticoagulant | response to alkaloid | cellular response to steroid hormone stimulus | regulation of regulated secretory pathway | positive regulation of intracellular transport | response to cAMP | cellular response to dexamethasone stimulus | negative regulation of cell cycle | negative regulation of protein metabolic process | response to fungicide | regulation of cell communication | cysteine-type endopeptidase regulator activity involved in apoptotic process | regulation of membrane permeability | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | response to organic cyclic compound | cell development | regulation of endocytosis | positive regulation of synaptic vesicle clustering | extrinsic apoptotic signaling pathway in absence of ligand | peptidase inhibitor activity | enzyme regulator activity | anatomical structure morphogenesis | regulation of endopeptidase activity | response to biotic stimulus | regulation of synaptic vesicle recycling | reproductive structure development | developmental process | organelle organization | cellular response to interleukin-1 | spermatogenesis | regulation of transport | modulation by virus of host morphology or physiology | response to organonitrogen compound | response to electrical stimulus | response to lead ion | negative regulation of hydrolase activity | regulation of calcium ion-dependent exocytosis | central nervous system development | in utero embryonic development | positive regulation of metabolic process | regulation of synaptic plasticity | vesicle localization | regulation of execution phase of apoptosis | mitotic cell cycle checkpoint | female sex differentiation | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | response to steroid hormone | cysteine-type endopeptidase inhibitor activity | cell cycle checkpoint | negative regulation of cell death | aging | cellular response to erythropoietin | sexual reproduction | positive regulation of endocytosis | positive regulation of synaptic vesicle endocytosis | regulation of cellular component organization | response to ionizing radiation | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | response to glucocorticoid | regulation of neurotransmitter secretion | negative regulation by symbiont of host apoptotic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
mitochondrial matrix | exocytic vesicle | integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | synapse | mitochondrial inner membrane | organelle membrane | microtubule organizing center | nuclear membrane | cytoplasmic vesicle | cell | organelle outer membrane | intrinsic component of membrane | transport vesicle membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | presynapse | centrosome | protein-containing complex | secretory vesicle | endomembrane system | postsynapse | nuclear envelope | exocytic vesicle membrane | vesicle | transport vesicle | clathrin-coated pit | microtubule cytoskeleton | mitochondrion | synaptic vesicle | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | vesicle membrane | mitochondrial envelope | membrane-enclosed lumen | outer membrane | synaptic vesicle membrane | mitochondrial membrane | cytosol | intracellular vesicle | cytoskeleton | Bcl-2 family protein complex | intracellular | cell junction | membrane | cytoplasmic vesicle membrane
