QuickView for CAB1;jsessionid=03B0326F642992172BC2856D649ACDC1;jsessionid=A3B22A7EDCF21729DB36082247F7820F (gene)

Gene Symbol:

CACNB1 Homo sapiens

Full name:

calcium voltage-gated channel auxiliary subunit beta 1

Synonyms:

CAB1, CACNLB1, CCHLB1, voltage-dependent L-type calcium channel subunit beta-1, calcium channel voltage-dependent subunit beta 1, calcium channel, L type, beta 1 polypeptide, calcium channel, voltage-dependent, beta 1 subunit, dihydropyridine-sensitive L-type, calcium channel beta-1 subunit

Genomic Location:

Chr 17: 34583235-34607427

Description:

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs...

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The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  MAZR_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  TGANNYRGCA_TCF11MAFG_01 ,  PPARA_01 ,  GCANCTGNY_MYOD_Q6 ,  SREBP1_Q6 ,  CTAWWWATA_RSRFC4_Q2 ,  CEBPB_01 ,  GGGGCCC_MIR296 ,  CAGGTA_AREB6_01 ,  LFA1_Q6 ,  CEBP_01 ,  CTCAGGG_MIR125B_MIR125A ,  NF1_Q6 ,  GTGCCAA_MIR96 ,  AGGTGCA_MIR500 ,  NF1_Q6_01 ,  MYOGENIN_Q6 ,  CCAGGGG_MIR331 ,  CTGAGCC_MIR24 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-500

Cytogenetic Map:

17q12

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