QuickView for CAMLG;jsessionid=7E47B7ECBE69C9EE9D69C12452DAE4E8;jsessionid=DC9FA15F160D6495C4471868F9572DFA;jsessionid=ACA7E5FCA7A7DB7180034DAB69EB039D;jsessionid=331ADBC5A8D0570A1EBC0B307B4828D6 (gene)

Gene Symbol:

CAMLG Homo sapiens

Full name:

calcium modulating ligand

Synonyms:

CAML, GET2, calcium signal-modulating cyclophilin ligand, calcium-modulating cyclophilin ligand, cyclophilin B-binding protein

Genomic Location:

Chr 5: 134102105-134115746

Description:

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin...

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The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  GR_Q6_01 ,  GGGYGTGNY_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  EN1_01 ,  YY1_02 ,  TCCATTKW_UNKNOWN

Cytogenetic Map:

5q31.1

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