QuickView for CASP-2;jsessionid=5DEB2FCE89368D47002682B883EC5C23;jsessionid=79CD2949A991C82D8C5BAB5026C3A49D;jsessionid=9BA78DF8E319A8ED2DFA32F79AE09B94;jsessionid=A0AC75FCBA3DA7783C2747E6A0DCD2E5 (gene)
- Gene Symbol:
- Casp2
Mus musculus - Full name:
- caspase 2
- Synonyms:
- CASP-2, ICH-1, NEDD-2, Nedd2, caspase-2, neural precursor cell expressed developmentally down-regulated protein 2, protease ICH-1
- Genomic Location:
- Chr 6: 42215038-42232495
- Description:
-
This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cysteine-type endopeptidase activity involved in apoptotic process | hydrolase activity | cysteine-type peptidase activity | catalytic activity | protein domain specific binding | identical protein binding | cysteine-type endopeptidase activity | protein binding | endopeptidase activity | peptidase activity
GO Biological Process
regulation of cell cycle process | developmental process involved in reproduction | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | negative regulation of cellular process | protein processing | cell differentiation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of neuron death | cellular process | extrinsic apoptotic signaling pathway | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of apoptotic process | regulation of cell cycle | regulation of cellular process | regulation of apoptotic process | signal transduction involved in mitotic DNA damage checkpoint | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | regulation of cell cycle phase transition | programmed cell death | reproduction | cysteine-type peptidase activity | apoptotic process | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | cellular response to DNA damage stimulus | positive regulation of cell cycle | signal transduction in response to DNA damage | cellular response to stress | cell cycle | regulation of cell cycle arrest | positive regulation of neuron death | protein maturation | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | programmed cell death involved in cell development | mitotic G1 DNA damage checkpoint | cell communication | regulation of neuron apoptotic process | positive regulation of signal transduction | cysteine-type endopeptidase activity | apoptotic signaling pathway | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | protein metabolic process | G1 DNA damage checkpoint | positive regulation of neuron apoptotic process | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | positive regulation of cell death | organic substance metabolic process | cell death | gene expression | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | negative regulation of cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | signaling | endopeptidase activity | cell development | extrinsic apoptotic signaling pathway in absence of ligand | signal transduction involved in DNA damage checkpoint | developmental process | positive regulation of cell cycle process | mitotic G1/S transition checkpoint | signal transduction involved in mitotic G1 DNA damage checkpoint | mitotic cell cycle checkpoint | negative regulation of cell cycle process | peptidase activity | regulation of cell death | ectopic germ cell programmed cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | intracellular | membrane
