QuickView for CCBL1;jsessionid=1DD4AD4EE1E7267DE268D430276E9B0E;jsessionid=EB1776A17F3E470E66E5222A2252A287;jsessionid=0E91E835E317C81C3D238010A838A221 (gene)

Gene Symbol:

KYAT1 Homo sapiens

Full name:

kynurenine aminotransferase 1

Synonyms:

CCBL1, GTK, KAT1, KATI, kynurenine--oxoglutarate transaminase 1, beta-lysase, kidney, cysteine conjugate beta lyase 1, cysteine conjugate-beta lyase, cytoplasmic, cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase), cysteine-S-conjugate beta-lyase, glutamine transaminase K, glutamine--phenylpyruvate transaminase, glutamine-phenylpyruvate aminotransferase, kyneurenine aminotransferase, kynurenine aminotransferase I, kynurenine--oxoglutarate transaminase I

Genomic Location:

Chr 9: 130635213-130684175

Description:

This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode differen...

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This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  SMTTTTGT_UNKNOWN ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  CREB_Q4 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CREBP1_Q2 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  MGGAAGTG_GABP_B ,  GCCNNNWTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  TGACGTCA_ATF3_Q6 ,  CCGNMNNTNACG_UNKNOWN ,  SRY_02 ,  CREB_Q2_01 ,  CREB_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-34

Cytogenetic Map:

9q34.11

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