QuickView for CCL2;jsessionid=8838F6B264F425CDD2C620D306F7AB40;jsessionid=2B1189DA42F5009D184C12121971E516;jsessionid=AE1E6CFD0ED0523519B64F22183140F1 (gene)

Gene Symbol:

Ccl2 Mus musculus

Full name:

chemokine (C-C motif) ligand 2

Synonyms:

AI323594, HC11, JE, MCAF, MCP-1, MCP1, SMC-CF, Scya2, Sigje, C-C motif chemokine 2, monocyte chemoattractant protein 1, monocyte chemotactic protein 1, platelet-derived growth factor-inducible protein JE, small-inducible cytokine A2

Genomic Location:

Chr 11: 81849079-81850954

Description:

This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfam...

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This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT_01 ,  STAT3_01 ,  FOXJ2_02 ,  STAT5A_01 ,  STAT5B_01 ,  HNF6_Q6 ,  TEL2_Q6 ,  AML_Q6 ,  ETS_Q4 ,  TGCCTTA_MIR124A ,  RACCACAR_AML_Q6 ,  RYTTCCTG_ETS2_B ,  TGGAAA_NFAT_Q4_01 ,  TTCYNRGAA_STAT5B_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

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