QuickView for CCL2;jsessionid=8838F6B264F425CDD2C620D306F7AB40;jsessionid=2B1189DA42F5009D184C12121971E516;jsessionid=A93BEF527AB94AC69DF7E5A68ABBD678 (gene)
- Gene Symbol:
- Ccl2
Rattus norvegicus - Full name:
- C-C motif chemokine ligand 2
- Synonyms:
- MCP-1, Scya2, Sigje, C-C motif chemokine 2, chemokine (C-C motif) ligand 2, immediate-early serum-responsive JE protein, immediate-early serum-responsive protein JE, monocyte chemoattractant protein 1, monocyte chemotactic protein 1, small inducible cytokine A2, small inducible gene JE
- Genomic Location:
- Chr 10: 70256263-70258061
- Description:
-
a monocyte chemoattractant protein
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
chemokine activity | CCR chemokine receptor binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | molecular function regulator | anion binding | CCR2 chemokine receptor binding | ion binding | chemokine receptor binding | heparin binding | protein binding | receptor regulator activity | G-protein coupled receptor binding | receptor ligand activity | cytokine activity | glycosaminoglycan binding
GO Biological Process
positive regulation of cell killing | response to cyclosporin A | response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of intracellular protein transport | response to nutrient levels | negative regulation of immune system process | macrophage chemotaxis | macrophage migration | response to ATP | response to cytokine | response to interleukin-1 | cellular response to glucose stimulus | positive regulation of cellular component organization | negative regulation of lymphocyte chemotaxis | cell motility | regulation of cell morphogenesis | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | cellular response to platelet-derived growth factor stimulus | positive regulation of apoptotic process | regulation of localization | regulation of cell cycle G1/S phase transition | positive regulation of collagen metabolic process | regulation of programmed cell death | regulation of immune system process | response to hormone | regulation of cell shape | negative regulation of vascular endothelial cell proliferation | negative regulation of neuron death | negative regulation of cellular process | response to dexamethasone | cellular response to tumor necrosis factor | positive regulation of lymphocyte activation | regulation of protein localization to membrane | cell differentiation | positive regulation of epithelial cell proliferation | chemokine-mediated signaling pathway | defense response | nervous system development | cellular response to extracellular stimulus | response to drug | cellular chemical homeostasis | regulation of leukocyte mediated cytotoxicity | regulation of G1/S transition of mitotic cell cycle | neurogenesis | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | response to antibiotic | regulation of neuron death | positive regulation of GTPase activity | response to organophosphorus | cellular process | eosinophil chemotaxis | positive regulation of macrophage migration | regulation of cell motility | localization | cellular homeostasis | positive regulation of synaptic transmission | T cell extravasation | positive regulation of immune effector process | chemokine activity | negative regulation of G1/S transition of mitotic cell cycle | response to progesterone | response to estradiol | female pregnancy | multicellular organismal reproductive process | regulation of chemotaxis | negative regulation of apoptotic process | response to hypoxia | regulation of monocyte chemotaxis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | granulocyte chemotaxis | positive regulation of epithelial cell apoptotic process | response to peptide hormone | positive regulation of apoptotic cell clearance | cellular response to retinoic acid | regeneration | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | parturition | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | negative regulation of chemotaxis | cellular response to molecule of bacterial origin | regulation of cellular extravasation | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | MAPK cascade | calcium ion homeostasis | response to transforming growth factor beta | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | helper T cell extravasation | regulation of vasculature development | response to stimulus | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | cellular response to fibroblast growth factor stimulus | positive regulation of immune complex clearance by monocytes and macrophages | neutrophil chemotaxis | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | cellular response to xenobiotic stimulus | response to stress | negative regulation of natural killer cell chemotaxis | positive regulation of cellular protein localization | regulation of cell proliferation | lymphocyte chemotaxis | negative regulation of angiogenesis | response to peptide | positive regulation of cell-cell adhesion | regulation of cell cycle phase transition | response to glucose | positive regulation of cell activation | positive regulation of endothelial cell apoptotic process | reproduction | negative regulation of leukocyte chemotaxis | response to alcohol | response to temperature stimulus | response to molecule of bacterial origin | positive regulation of T cell activation | cellular response to organic cyclic compound | regulation of phagocytosis | regulation of protein transport | G-protein coupled receptor signaling pathway | monocyte chemotaxis | regulation of wound healing | protein modification process | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | macromolecule modification | cell chemotaxis | regulation of intracellular transport | molecular function regulator | metal ion homeostasis | response to ethanol | leukocyte migration | astrocyte cell migration | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | protein kinase B signaling | cellular response to interleukin-6 | cellular response to hormone stimulus | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | positive regulation of response to wounding | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of monocyte chemotaxis | negative regulation of mitotic cell cycle phase transition | multicellular organism development | response to activity | cell migration | cellular glucose homeostasis | cellular response to peptide hormone stimulus | regulation of MAPK cascade | phosphorus metabolic process | response to amino acid | response to purine-containing compound | regulation of collagen biosynthetic process | response to fatty acid | cellular response to insulin stimulus | regulation of catalytic activity | regulation of granulocyte chemotaxis | regulation of phosphorylation | positive regulation of calcium ion import | regulation of T cell activation | positive regulation of chemotaxis | negative regulation of lymphocyte migration | cellular response to ATP | response to ketone | response to lipid | cellular response to peptide | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | cellular response to high density lipoprotein particle stimulus | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | lymphocyte migration | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | response to nutrient | regulation of endothelial cell apoptotic process | chemokinesis | positive regulation of hydrolase activity | response to platelet-derived growth factor | positive regulation of cell migration | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | cellular response to glucocorticoid stimulus | regulation of immune complex clearance by monocytes and macrophages | phosphorylation | response to toxic substance | regulation of GTPase activity | response to xenobiotic stimulus | regulation of epithelial cell apoptotic process | protein phosphorylation | regulation of tumor necrosis factor production | positive regulation of macrophage chemotaxis | response to gamma radiation | cation homeostasis | cellular response to corticosteroid stimulus | regulation of leukocyte migration | phosphate-containing compound metabolic process | positive regulation of cellular extravasation | cellular response to drug | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | positive regulation of leukocyte chemotaxis | inflammatory response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | response to retinoic acid | cellular response to fatty acid | cellular response to lipoprotein particle stimulus | regulation of mitotic cell cycle | regulation of apoptotic cell clearance | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | regulation of signaling receptor activity | maternal process involved in female pregnancy | maternal process involved in parturition | receptor regulator activity | chronic inflammatory response | negative regulation of epithelial cell proliferation | protein metabolic process | cellular response to nutrient | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | eosinophil migration | response to wounding | response to antineoplastic agent | response to mechanical stimulus | positive regulation of mononuclear cell migration | regulation of intracellular signal transduction | response to insulin | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of protein targeting | positive regulation of leukocyte activation | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | cellular response to carbohydrate stimulus | regulation of vesicle-mediated transport | negative regulation of endothelial cell proliferation | chemical homeostasis | positive regulation of cell death | receptor ligand activity | immune response | cytokine activity | organic substance metabolic process | response to vitamin | animal organ development | positive regulation of ion transport | regulation of endothelial cell proliferation | regulation of cell activation | negative regulation of cellular component movement | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of phagocytosis | response to heat | ion homeostasis | regulation of phosphate metabolic process | positive regulation of wound healing | cytoskeleton organization | cellular response to steroid hormone stimulus | response to interferon-gamma | positive regulation of cytokine production | positive regulation of intracellular transport | negative regulation of glial cell apoptotic process | positive regulation of MAPK cascade | cellular response to dexamethasone stimulus | regulation of lymphocyte chemotaxis | positive regulation of protein transport | transforming growth factor beta receptor signaling pathway | leukocyte migration involved in inflammatory response | negative regulation of cell cycle | cellular response to estradiol stimulus | regulation of calcium ion import | regulation of response to wounding | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | signaling | response to organic cyclic compound | regulation of endocytosis | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | response to biotic stimulus | negative regulation of leukocyte migration | regulation of developmental process | regulation of ion transport | developmental process | organelle organization | cellular response to interleukin-1 | regulation of calcium ion transport | cellular protein modification process | positive regulation of protein targeting to membrane | cellular extravasation | vascular endothelial growth factor receptor signaling pathway | regulation of transport | response to vitamin B3 | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of leukocyte mediated cytotoxicity | innate immune response | negative regulation of vasculature development | response to fibroblast growth factor | response to organonitrogen compound | cellular metal ion homeostasis | regulation of vascular endothelial growth factor production | T cell migration | regulation of macrophage chemotaxis | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular response to macrophage colony-stimulating factor stimulus | immune system process | positive regulation of collagen biosynthetic process | cellular metabolic process | negative regulation of cell cycle process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | response to interleukin-6 | negative regulation of cell death | neutrophil migration | aging | carbohydrate homeostasis | chemotaxis | divalent inorganic cation homeostasis | negative regulation of locomotion | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of lymphocyte migration | regulation of cellular component organization | positive regulation of calcium ion transport | response to ionizing radiation | response to other organism | positive regulation of signaling | signal transduction | mononuclear cell migration | regulation of signaling | animal organ regeneration | positive regulation of nitric-oxide synthase biosynthetic process | response to glucocorticoid | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | distal axon | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | presynapse | cell projection | endomembrane system | perikaryon | C-fiber | vesicle | perinuclear region of cytoplasm | extracellular region | membrane-bounded organelle | organelle | axon terminus | extracellular space | axon | neuron projection terminus | rough endoplasmic reticulum | intracellular vesicle | endocytic vesicle | intracellular
