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QuickView for CD95L;jsessionid=134B3A62A96FE248B8BBF1906E597376;jsessionid=B8592E1E7554EA7A72DB1679A494FBED (gene)


Gene Symbol:
Faslg Rattus norvegicus Rattus norvegicus
Full name:
Fas ligand
Synonyms:
Apt1Lg1, CD95-L, Fasl, Tnfsf6, Tnlg1a, tumor necrosis factor ligand superfamily member 6, Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand), CD95 ligand, CD95L protein, Fas antigen ligand, Fas ligand (TNF superfamily, member 6), Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand), tumor necrosis factor ligand 1a
Genomic Location:
Chr 13: 77472950-77480210
Description:
ligand that binds the Fas receptor; plays a role in induction of apoptosis
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

signaling receptor binding | cytokine receptor binding | molecular function regulator | death receptor binding | tumor necrosis factor receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | tumor necrosis factor receptor superfamily binding

GO Biological Process

RNA metabolic process | regulation of cysteine-type endopeptidase activity | response to lipopolysaccharide | endosomal lumen acidification | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | cytosolic calcium ion transport | regulation of localization | regulation of programmed cell death | eye development | necroptotic process | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | cellular chemical homeostasis | regulation of neuron death | necroptotic signaling pathway | cellular process | localization | cellular homeostasis | extrinsic apoptotic signaling pathway | metal ion transport | anion homeostasis | programmed necrotic cell death | negative regulation of nucleic acid-templated transcription | endomembrane system organization | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of epithelial cell apoptotic process | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | calcium ion homeostasis | pH reduction | inflammatory cell apoptotic process | calcium ion transport into cytosol | regulation of vasculature development | response to stimulus | intracellular pH reduction | positive regulation of protein metabolic process | positive regulation of peptidase activity | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | negative regulation of angiogenesis | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of endothelial cell apoptotic process | cellular localization | divalent metal ion transport | cellular monovalent inorganic anion homeostasis | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | extrinsic apoptotic signaling pathway via death domain receptors | negative regulation of metabolic process | cellular biosynthetic process | positive regulation of ERBB signaling pathway | molecular function regulator | metal ion homeostasis | regulation of nucleic acid-templated transcription | apoptotic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of peptidase activity | calcium ion transmembrane transport | regulation of catalytic activity | ion transmembrane transport | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | regulation of endothelial cell apoptotic process | positive regulation of hydrolase activity | T cell apoptotic process | biosynthetic process | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of endopeptidase activity | positive regulation of neuron death | programmed cell death involved in cell development | regulation of epithelial cell apoptotic process | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | sensory organ development | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | eye morphogenesis | regulation of neuron apoptotic process | regulation of intracellular pH | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of RNA metabolic process | apoptotic signaling pathway | positive regulation of molecular function | release of sequestered calcium ion into cytosol | cation transmembrane transport | cellular chloride ion homeostasis | regulation of signaling receptor activity | receptor regulator activity | response to organic substance | regulation of pH | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | chloride ion homeostasis | cell surface receptor signaling pathway | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | retinal cell programmed cell death | chemical homeostasis | calcium ion transport | positive regulation of cell death | receptor ligand activity | immune response | nucleobase-containing compound metabolic process | cytokine activity | organic substance metabolic process | regulation of sequestering of calcium ion | regulation of epidermal growth factor receptor signaling pathway | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of programmed cell death | ion homeostasis | inorganic cation transmembrane transport | vesicle organization | transcription, DNA-templated | regulation of cellular pH | regulation of cell communication | transmembrane transport | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | cellular monovalent inorganic cation homeostasis | cell development | regulation of ERBB signaling pathway | positive regulation of epidermal growth factor receptor signaling pathway | anatomical structure morphogenesis | release of sequestered calcium ion into cytosol by endoplasmic reticulum | regulation of endopeptidase activity | cation transport | cellular macromolecule biosynthetic process | endosome organization | response to biotic stimulus | regulation of developmental process | developmental process | organelle organization | negative regulation of transcription by RNA polymerase II | necrotic cell death | negative regulation of vasculature development | cellular metal ion homeostasis | heterocycle metabolic process | positive regulation of metabolic process | ion transport | immune system process | cellular metabolic process | regulation of cell death | divalent inorganic cation homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | intrinsic component of membrane | cytoplasmic vesicle lumen | external side of plasma membrane | cytoplasm | intracellular organelle | membrane microdomain | plasma membrane | membrane raft | vacuole | vesicle | perinuclear region of cytoplasm | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | cell periphery | membrane-enclosed lumen | lysosomal lumen | plasma membrane raft | intracellular vesicle | cell surface | intracellular | caveola | membrane | vesicle lumen