QuickView for CFD;jsessionid=78F73C851409D5C2F864F21E98F7DD3E;jsessionid=87B58AFAD3A565F6E6F7718A50A4A1AD;jsessionid=A3180D7966A7F4C42D18FF5078CDB1F0;jsessionid=8F4EDA634D84D1FDE6A368E77D7D31CE;jsessionid=F181F75C2A35808116E0F6023B1260BA (gene)

Gene Symbol:

CFD Homo sapiens

Full name:

complement factor D

Synonyms:

ADIPSIN, ADN, DF, PFD, complement factor D, C3 convertase activator, D component of complement (adipsin), complement factor D preproprotein, properdin factor D

Genomic Location:

Chr 19: 810665-814624

Description:

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mut...

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This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Cytogenetic Map:

19p13.3

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