QuickView for CGRP-I;jsessionid=25B6A1CD254B8E9C56A31ECB6DF85A65;jsessionid=F5868B308B6153D375635B8D1DEE4B1C (gene)
- Gene Symbol:
- Calca
Rattus norvegicus - Full name:
- calcitonin-related polypeptide alpha
- Synonyms:
- CAL6, CGRP, Cal1, Calc, RATCAL6, calcitonin, calcitonin gene-related peptide 1, CGRP-I, alpha-type CGRP, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha
- Genomic Location:
- Chr 1: 172686168-172691061
- Description:
-
an inhibitor of lactotroph function and a potent vasodilator
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
protein-containing complex binding | signaling receptor binding | hormone activity | molecular function regulator | identical protein binding | protein binding | receptor regulator activity | neuropeptide hormone activity | G-protein coupled receptor binding | receptor ligand activity | calcitonin receptor binding
GO Biological Process
negative regulation of G-protein coupled receptor protein signaling pathway | regulation of blood vessel diameter | regulation of muscle system process | negative regulation of immune system process | detection of stimulus | response to cytokine | cell motility | regulation of cellular localization | intracellular signal transduction | negative regulation of muscle contraction | regulation of localization | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | negative regulation of tissue remodeling | defense response | regulation of smooth muscle contraction | epithelial cell migration | cellular chemical homeostasis | negative regulation of osteoclast differentiation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of bone remodeling | cellular process | neuropeptide signaling pathway | localization | cellular homeostasis | negative regulation of signaling | epithelium migration | female pregnancy | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | response to growth factor | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | endothelial cell proliferation | negative regulation of cellular metabolic process | regulation of myeloid leukocyte differentiation | regulation of neurological system process | regulation of cell differentiation | positive regulation of interleukin-8 production | regulation of cellular process | regulation of metabolic process | G-protein coupled receptor internalization | regulation of cytosolic calcium ion concentration | neurological system process involved in regulation of systemic arterial blood pressure | response to nerve growth factor | positive regulation of cellular protein metabolic process | negative regulation of bone resorption | cellular component organization | calcium ion homeostasis | response to stimulus | vasculature development | response to pain | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of blood vessel size | negative regulation of neurological system process | response to stress | endothelial cell migration | regulation of blood circulation | sensory perception of temperature stimulus | regulation of heart rate | reproduction | cardiovascular system development | response to temperature stimulus | negative regulation of transport | hormone activity | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | monocyte chemotaxis | negative regulation of hemopoiesis | protein modification process | regulation of systemic arterial blood pressure by baroreceptor feedback | regulation of cell adhesion | macromolecule modification | cell chemotaxis | activation of protein kinase activity | molecular function regulator | metal ion homeostasis | negative regulation of blood pressure | detection of temperature stimulus involved in sensory perception | leukocyte migration | positive regulation of macrophage differentiation | regulation of nucleic acid-templated transcription | detection of abiotic stimulus | locomotion | regulation of calcium ion transport into cytosol | system development | calcitonin gene-related peptide receptor signaling pathway | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | cell migration | phosphorus metabolic process | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of muscle contraction | regulation of catalytic activity | cellular response to nerve growth factor stimulus | regulation of phosphorylation | regulation of ossification | amylin receptor signaling pathway | positive regulation of interleukin-1 alpha production | regulation of gene expression | nervous system process | regulation of blood pressure | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | neuromuscular junction development | cellular ion homeostasis | negative regulation of myeloid cell differentiation | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | vesicle-mediated transport | synapse organization | positive regulation of cell differentiation | second-messenger-mediated signaling | positive regulation of myeloid cell differentiation | cellular response to cytokine stimulus | cell proliferation | sensory perception of pain | regulation of cellular protein metabolic process | positive regulation of ossification | phosphorylation | negative regulation of ion transport | detection of temperature stimulus involved in sensory perception of pain | regulation of heart contraction | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | regulation of interleukin-1 production | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of interleukin-1 production | receptor internalization | inflammatory response | negative regulation of calcium ion transport | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of tube size | negative regulation of calcium ion transport into cytosol | negative adaptation of signaling pathway | positive regulation of molecular function | regulation of signaling receptor activity | activation of adenylate cyclase activity | receptor regulator activity | multicellular organismal response to stress | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of hemopoiesis | cAMP-mediated signaling | epithelial cell proliferation | regulation of kinase activity | import into cell | detection of stimulus involved in sensory perception | negative regulation of ossification | anatomical structure development | neuropeptide hormone activity | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | vasodilation | leukocyte cell-cell adhesion | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of tube diameter | regulation of bone resorption | regulation of tissue remodeling | chemical homeostasis | endocytosis | behavior | cell adhesion | receptor ligand activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | desensitization of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | response to heat | ion homeostasis | regulation of phosphate metabolic process | phospholipase C-activating G-protein coupled receptor signaling pathway | cell-cell adhesion | positive regulation of cytokine production | sensory perception | regulation of osteoclast differentiation | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | regulation of macrophage differentiation | negative regulation of signal transduction | signaling | feeding behavior | regulation of transcription, DNA-templated | negative regulation of systemic arterial blood pressure | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | developmental process | regulation of calcium ion transport | cellular protein modification process | detection of temperature stimulus | regulation of transport | receptor metabolic process | cellular metal ion homeostasis | negative regulation of smooth muscle contraction | embryo implantation | negative regulation of bone remodeling | positive regulation of metabolic process | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | response to tumor necrosis factor | ameboidal-type cell migration | cellular response to organic substance | positive regulation of blood vessel diameter | circulatory system development | aging | chemotaxis | divalent inorganic cation homeostasis | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | signal transduction | mononuclear cell migration | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | distal axon | terminal bouton | cytoplasm | intracellular organelle | presynapse | cell projection | extracellular region | membrane-bounded organelle | nucleus | organelle | axon terminus | extracellular space | axon | neuron projection terminus | intracellular
