QuickView for CHD3;jsessionid=8AAC087768642ABDDDB4719F787185A3;jsessionid=E336EFCDDA484782D4518F62D916942C;jsessionid=6F1DC3FBD19FEB522606EE734E27DFD5;jsessionid=A892886EAE19892F9568D3F38212E0AB (gene)

Gene Symbol:

CHD3 Homo sapiens

Full name:

chromodomain helicase DNA binding protein 3

Synonyms:

Mi-2a, Mi2-ALPHA, ZFH, chromodomain-helicase-DNA-binding protein 3, ATP-dependent helicase CHD3, CHD-3, hZFH, mi-2 autoantigen 240 kDa protein, zinc finger helicase, zinc-finger helicase (Snf2-like)

Genomic Location:

Chr 17: 7728849-7756246

Description:

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin b...

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This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTCTTCC_MIR7 ,  CAGGGTC_MIR504 ,  TCCCCAC_MIR491

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-491 ,  Predicted Gene Targets for miR-504

Cytogenetic Map:

17p13.1

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