QuickView for CHEK1;jsessionid=B95514E16411741F3CF0A79500D5F5A8;jsessionid=50F71EA6DC706F2E5763808F272AD2F2 (gene)
- Gene Symbol:
- Chek1
Mus musculus - Full name:
- checkpoint kinase 1
- Synonyms:
- C85740, Chk1, rad27, serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, checkpoint kinase 1 homolog, rad27 homolog
- Genomic Location:
- Chr 9: 36516067-36534212
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
histone threonine kinase activity | histone kinase activity (H3-T11 specific) | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | histone kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
response to radiation | nucleus organization | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | histone threonine kinase activity | intracellular signal transduction | peptidyl-amino acid modification | negative regulation of cellular process | histone modification | regulation of organelle organization | regulation of mitotic centrosome separation | negative regulation of DNA metabolic process | regulation of DNA repair | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | negative regulation of DNA biosynthetic process | chromatin organization | developmental growth | regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage | regulation of mitotic nuclear division | histone kinase activity (H3-T11 specific) | regulation of histone modification | inner cell mass cell proliferation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of histone H3-K9 acetylation | DNA damage induced protein phosphorylation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | response to UV | response to stimulus | peptidyl-threonine phosphorylation | regulation of DNA recombination | regulation of mitotic cell cycle phase transition | regulation of centrosome cycle | cellular response to light stimulus | response to stress | negative regulation of G2/M transition of mitotic cell cycle | regulation of cell proliferation | regulation of double-strand break repair | regulation of cell cycle phase transition | protein serine/threonine kinase activity | programmed cell death | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | embryo development | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | regulation of cell cycle G2/M phase transition | response to light stimulus | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | multicellular organism development | negative regulation of cell cycle G2/M phase transition | phosphorus metabolic process | cellular response to DNA damage stimulus | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | chromatin-mediated maintenance of transcription | cellular response to radiation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | positive regulation of gene expression, epigenetic | negative regulation of mitotic nuclear division | cell proliferation | regulation of cellular protein metabolic process | G2/M transition of mitotic cell cycle | phosphorylation | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to UV | chordate embryonic development | cell communication | regulation of cellular metabolic process | chromatin remodeling | regulation of protein metabolic process | cell cycle G2/M phase transition | apoptotic process involved in development | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | histone phosphorylation | regulation of double-strand break repair via homologous recombination | regulation of mitotic cell cycle | regulation of microtubule-based process | protein metabolic process | histone kinase activity | DNA metabolic process | anatomical structure development | mitotic cell cycle | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | signal transduction involved in G2 DNA damage checkpoint | protein kinase activity | organic substance metabolic process | cell death | negative regulation of biosynthetic process | regulation of chromosome organization | blastocyst development | negative regulation of cell cycle | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | signal transduction involved in DNA damage checkpoint | kinase activity | developmental process | organelle organization | regulation of DNA biosynthetic process | blastocyst growth | cellular protein modification process | regulation of histone acetylation | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | heterocycle metabolic process | in utero embryonic development | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | histone H3-T11 phosphorylation | DNA damage checkpoint | cell cycle checkpoint | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization
GO Cellular Component
condensed nuclear chromosome | chromosome | intracellular membrane-bounded organelle | microtubule organizing center | cell | nuclear lumen | replication fork | cytoplasm | intracellular organelle | centrosome | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | microtubule cytoskeleton | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | intracellular | condensed chromosome
