QuickView for COL1A1;jsessionid=DC3FC5ABB85E9CCFDCCCAC447384EEB0;jsessionid=CBBD3CA3D9D08D3C9A985B319A7F9B6E (gene)

Gene Symbol:

Col1a1 Mus musculus

Full name:

collagen, type I, alpha 1

Synonyms:

Col1a-1, Cola-1, Cola1, Mov-13, Mov13, collagen alpha-1(I) chain, alpha-1 type 1 collagen, alpha-1 type I collagen, procollagen, type I, alpha 1

Genomic Location:

Chr 11: 94797584-94813181

Description:

This gene encodes the alpha-1 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die ...

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This gene encodes the alpha-1 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

COMP1_01 ,  CP2_01 ,  NFY_Q6 ,  SRF_Q6 ,  NFY_C ,  TATA_C ,  TATA_01 ,  NFY_01 ,  CCAWNWWNNNGGC_UNKNOWN ,  MAF_Q6 ,  ALPHACP1_01 ,  ATF1_Q6 ,  TFIIA_Q6 ,  MYOGENIN_Q6 ,  NFY_Q6_01 ,  E2A_Q2 ,  SRF_Q5_01 ,  MEF2_Q6_01 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  ACTACCT_MIR196A_MIR196B ,  GCTTGAA_MIR498 ,  AGGAAGC_MIR5163P ,  AAGCACA_MIR218 ,  CTTTGCA_MIR527 ,  TAATAAT_MIR126 ,  WTTGKCTG_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGANTCA_AP1_C ,  TAATTA_CHX10_01 ,  CAGGTG_E12_Q6 ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  GATTGGY_NFY_Q6_01 ,  GGGTGGRR_PAX4_03 ,  TAAWWATAG_RSRFC4_Q2 ,  GGGCGGR_SP1_Q6 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-29

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