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QuickView for CRFR1;jsessionid=35146CB94A9CFD238FA70FF63DB801DC;jsessionid=D8B1BD854C761F4F7F9D0739E7E08BEB (gene)


Gene Symbol:
Crhr1 Rattus norvegicus Rattus norvegicus
Full name:
corticotropin releasing hormone receptor 1
Synonyms:
CRFR1, CRH-R 1, corticotropin-releasing factor receptor 1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRH-R-1, CRH-R1, corticotrophin releasing hormone receptor 1, corticotropin releasing hormone 1
Genomic Location:
Chr 10: 93311878-93354303
Description:
This gene encodes a member of the G-protein coupled receptor family. The encoded protein is a receptor for corticotropin-releasing factor (CRH) and urocortin (UCN). The interaction of this protein with CRH and UCN triggers G-protein coupled signaling. This protein plays a pivotal role in mediating the CRH-elicited effects in depression and anxiety....
Orthologs:
Homo sapiens Mus musculus D. melanogaster C. elegans Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

peptide binding | peptide hormone binding | neurotransmitter binding | transmembrane signaling receptor activity | protein-containing complex binding | corticotrophin-releasing factor receptor activity | G-protein coupled receptor activity | corticotropin-releasing hormone receptor activity | amide binding | signaling receptor activity | hormone binding | protein binding | corticotropin-releasing hormone binding | peptide receptor activity | G-protein alpha-subunit binding

GO Biological Process

positive regulation of immune response | behavioral response to pain | brain development | response to radiation | regulation of corticosterone secretion | regulation of cellular localization | intracellular signal transduction | regulation of localization | negative regulation of voltage-gated calcium channel activity | hormone secretion | response to immobilization stress | establishment of localization | regulation of immune system process | response to hormone | negative regulation of neuron death | negative regulation of cellular process | cell differentiation | nervous system development | response to drug | cellular chemical homeostasis | response to antibiotic | regulation of lipid transport | hormone-mediated signaling pathway | regulation of neuron death | cellular process | secretion | peptide hormone secretion | neuropeptide signaling pathway | regulation of catecholamine secretion | localization | cellular homeostasis | exploration behavior | positive regulation of synaptic transmission | negative regulation of signaling | visual learning | positive regulation of immune effector process | learning | negative regulation of secretion | response to hypoxia | diencephalon development | negative regulation of hormone secretion | response to peptide hormone | regulation of behavior | tissue development | regulation of immune response | regulation of cellular process | regulation of cytosolic calcium ion concentration | general adaptation syndrome, behavioral process | epithelium development | cellular response to organonitrogen compound | regulation of mast cell degranulation | calcium ion homeostasis | corticotrophin-releasing factor receptor activity | head development | G-protein coupled receptor activity | associative learning | response to stimulus | regulation of feeding behavior | response to pain | positive regulation of immune system process | response to cocaine | response to stress | hypothalamus development | positive regulation of mast cell degranulation | response to peptide | positive regulation of cell activation | negative regulation of transporter activity | secretion by cell | response to alcohol | negative regulation of transport | G-protein coupled receptor signaling pathway | modulation of chemical synaptic transmission | cell-cell signaling | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | regulation of intracellular transport | metal ion homeostasis | response to ethanol | positive regulation of exocytosis | response to nitrogen compound | cellular response to hormone stimulus | response to light stimulus | system development | response to oxygen levels | negative regulation of epinephrine secretion | regulation of signal transduction | negative regulation of secretion by cell | multicellular organism development | cellular response to peptide hormone stimulus | learning or memory | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | corticotropin-releasing hormone receptor activity | regulation of catalytic activity | regulation of hormone levels | regulation of hormone secretion | positive regulation of secretion | organic substance transport | nervous system process | cellular response to peptide | general adaptation syndrome | cellular ion homeostasis | behavioral response to ethanol | response to ammonium ion | positive regulation of cytosolic calcium ion concentration | regulation of mast cell activation | peptide transport | positive regulation of intracellular signal transduction | behavioral response to cocaine | second-messenger-mediated signaling | cognition | negative regulation of ion transmembrane transport | negative regulation of calcium ion transmembrane transporter activity | locomotory behavior | negative regulation of ion transport | regulation of calcium ion transmembrane transport | response to toxic substance | regulation of cyclase activity | regulation of voltage-gated calcium channel activity | response to xenobiotic stimulus | endocrine system development | cation homeostasis | positive regulation of regulated secretory pathway | peptide secretion | cellular cation homeostasis | endocrine process | cell communication | negative regulation of cation channel activity | negative regulation of calcium ion transport | cyclic-nucleotide-mediated signaling | regulation of endocrine process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | cellular calcium ion homeostasis | homeostatic process | limbic system development | cellular response to corticotropin-releasing hormone stimulus | positive regulation of transport | negative regulation of catecholamine secretion | multicellular organismal response to stress | fear response | response to organic substance | gland development | negative regulation of behavior | visual behavior | cAMP-mediated signaling | regulation of intracellular signal transduction | regulation of exocytosis | anatomical structure development | cell surface receptor signaling pathway | negative regulation of feeding behavior | corticotropin secretion | positive regulation of leukocyte activation | adrenal gland development | amide transport | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | behavior | hormone transport | positive regulation of mast cell activation | negative regulation of ion transmembrane transporter activity | animal organ development | forebrain development | regulation of cell activation | positive regulation of cAMP-mediated signaling | ion homeostasis | response to corticotropin-releasing hormone | response to alkaloid | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway | regulation of regulated secretory pathway | positive regulation of intracellular transport | regulation of adenylate cyclase activity | memory | adult behavior | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | signaling | feeding behavior | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | regulation of ion transport | developmental process | regulation of calcium ion transport | regulation of transport | regulation of cation channel activity | signal release | response to organonitrogen compound | locomotory exploration behavior | cellular metal ion homeostasis | epithelial cell differentiation | response to electrical stimulus | central nervous system development | response to anesthetic | regulation of synaptic plasticity | regulation of calcium ion transmembrane transporter activity | long-term synaptic potentiation | cellular response to organic substance | regulation of cell death | negative regulation of cell death | divalent inorganic cation homeostasis | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

dendritic spine | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | late endosome | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | multivesicular body | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | dendritic tree | apical part of cell | Golgi apparatus | cell projection | endomembrane system | neuron spine | postsynapse | plasma membrane | vesicle | endosome | membrane-bounded organelle | organelle | cell periphery | trans-Golgi network | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane