QuickView for CRYB2;jsessionid=7B86A2A8CAFB87D018A014C18E6BBFBA;jsessionid=795D99E33880612202421AB91C8AAD8B (gene)

Gene Symbol:

Crybb2 Mus musculus

Full name:

crystallin, beta B2

Synonyms:

Cryb-2, beta-crystallin B2, beta-crystallin Bp

Genomic Location:

Chr 5: 113487285-113497786

Description:

This gene is a member of the beta-crystallin family. Beta crystallins, along with alpha and gamma crystallins, are the major proteins found in the eye lens. These proteins maintain the refractive index of the lens whilst also maintaining its transparency. Since lens central fiber cells lose their nuclei during development, crystallins are made and ...

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This gene is a member of the beta-crystallin family. Beta crystallins, along with alpha and gamma crystallins, are the major proteins found in the eye lens. These proteins maintain the refractive index of the lens whilst also maintaining its transparency. Since lens central fiber cells lose their nuclei during development, crystallins are made and then retained throughout life, making them extremely stable proteins. Beta and gamma crystallins are considered be a superfamily and have a similar domain architecture, including four Greek Key motifs. Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. The protein encoded by this gene may have Ca2+-binding activity and could be associated with potential functions in the hippocampus and in sperm. Targeted knockout of this gene in mouse induces age-related cataract. A chain-terminating mutation in a similar gene in human was found to cause type 2 cerulean cataracts.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

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