QuickView for CSN6;jsessionid=695E27FF4ECD525B305279DCDBC9A1E8;jsessionid=BF19AA9E23A4B2940A6133BD511CBF19;jsessionid=192D4D1E14218B803A8DBC08351C78C8;jsessionid=C1B793631562418354BAEDEF37622450 (gene)

Gene Symbol:

COPS6 Homo sapiens

Full name:

COP9 signalosome subunit 6

Synonyms:

CSN6, MOV34-34KD, COP9 signalosome complex subunit 6, COP9 constitutive photomorphogenic homolog subunit 6, H_NH0506M12.12, JAB1-containing signalosome subunit 6, MOV34 homolog, 34 kD, SGN6, hVIP, vpr-interacting protein

Genomic Location:

Chr 7: 99524519-99527759

Description:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact...

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The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN

Cytogenetic Map:

7q22.1

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