QuickView for CXCR4;jsessionid=189F88D0448206D09B02DE014A2BA1A8;jsessionid=CAD102E11C34BC6235BD82D239E2A124;jsessionid=633697E5F580EB94CC644A99FAF27530;jsessionid=E8FC5C59F1D203C9DE59CA95A9FBFCF6 (gene)
- Gene Symbol:
- Cxcr4
Rattus norvegicus - Full name:
- C-X-C motif chemokine receptor 4
- Synonyms:
- C-X-C chemokine receptor type 4, CXC chemokine receptor, CXC-R4, CXCR-4, LESTR, SDF-1 receptor, chemokine (C-X-C motif) receptor 4, chemokine receptor (LCR1), fusin, leukocyte-derived seven transmembrane domain receptor, stromal cell-derived factor 1 receptor
- Genomic Location:
- Chr 13: 41308286-41312190
- Description:
-
G protein-coupled receptor for the chemokine stromal cell-derived factor-1; may have a role in brain development
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
actin binding | cytokine binding | transmembrane signaling receptor activity | enzyme binding | G-protein coupled receptor activity | myosin binding | ubiquitin binding | chemokine binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | signaling receptor activity | G-protein coupled chemoattractant receptor activity | ubiquitin-like protein binding | cytokine receptor activity | protein binding | ubiquitin protein ligase binding | C-C chemokine receptor activity | peptide receptor activity | chemokine receptor activity | G-protein coupled peptide receptor activity | drug binding | myosin light chain binding | C-C chemokine binding | C-X-C chemokine receptor activity
GO Biological Process
brain development | cell morphogenesis | positive regulation of locomotion | heart process | detection of stimulus | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | developmental process involved in reproduction | intracellular signal transduction | regulation of cell development | regulation of localization | morphogenesis of an epithelium | response to isoquinoline alkaloid | regulation of programmed cell death | neuron migration | positive regulation of developmental process | cell differentiation | endothelial cell differentiation | chemokine-mediated signaling pathway | detection of mechanical stimulus involved in sensory perception | nervous system development | response to drug | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | generation of neurons | membrane organization | sensory perception of mechanical stimulus | blood vessel morphogenesis | cellular process | response to morphine | regulation of cell motility | localization | cellular homeostasis | axon ensheathment | cell projection morphogenesis | epithelial tube morphogenesis | forebrain cell migration | neuron development | multicellular organismal reproductive process | regulation of chemotaxis | endomembrane system organization | response to hypoxia | axon guidance | positive regulation of nitrogen compound metabolic process | myelin maintenance | regulation of neuron projection development | tissue development | regulation of cell differentiation | gamete generation | cell recognition | regulation of angiogenesis | regulation of cellular process | leukocyte activation | positive regulation of cell growth | hematopoietic stem cell migration | regulation of metabolic process | regulation of cytosolic calcium ion concentration | heart contraction | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | calcium ion homeostasis | T cell activation | head development | G-protein coupled receptor activity | muscle contraction | branching involved in blood vessel morphogenesis | regulation of vasculature development | response to stimulus | vasculature development | cell morphogenesis involved in neuron differentiation | positive regulation of protein metabolic process | mononuclear cell proliferation | response to stress | neuron projection guidance | germ cell development | tube morphogenesis | sensory perception of temperature stimulus | epithelial cell development | ensheathment of neurons | telencephalon cell migration | regulation of dendrite extension | reproduction | cardiovascular system development | response to temperature stimulus | positive regulation of gliogenesis | blood circulation | G-protein coupled receptor signaling pathway | regulation of wound healing | regulation of oligodendrocyte differentiation | cell chemotaxis | metal ion homeostasis | blood vessel development | detection of temperature stimulus involved in sensory perception | detection of abiotic stimulus | locomotion | response to nitrogen compound | system development | response to oxygen levels | positive regulation of response to wounding | reproductive process | endothelium development | myelination | positive regulation of neuron projection development | multicellular organism development | response to activity | cell migration | regulation of phosphorylation | plasma membrane organization | positive regulation of calcium ion import | telencephalon development | artery development | detection of mechanical stimulus involved in sensory perception of pain | regulation of neuron differentiation | axon development | nervous system process | neuron recognition | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | response to ammonium ion | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of cell projection organization | cytokine-mediated signaling pathway | regulation of cellular component movement | axonogenesis | G-protein coupled chemoattractant receptor activity | positive regulation of cell differentiation | second-messenger-mediated signaling | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | sensory perception of pain | regulation of cellular protein metabolic process | angiogenesis | response to ultrasound | detection of temperature stimulus involved in sensory perception of pain | response to xenobiotic stimulus | cell morphogenesis involved in differentiation | cation homeostasis | cellular response to drug | cytokine receptor activity | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | heart development | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | striated muscle contraction | regulation of viral process | lymphocyte activation | calcium-mediated signaling | neuron differentiation | multicellular organism reproduction | ventricular septum development | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | response to organic substance | tissue morphogenesis | branching morphogenesis of an epithelial tube | response to mechanical stimulus | detection of stimulus involved in sensory perception | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | aorta development | endothelial tube morphogenesis | cell projection organization | positive regulation of cell development | positive regulation of glial cell differentiation | chemical homeostasis | immune response | neuron projection development | animal organ development | positive regulation of ion transport | forebrain development | T cell proliferation | ion homeostasis | neural precursor cell proliferation | regulation of phosphate metabolic process | positive regulation of wound healing | response to alkaloid | detection of mechanical stimulus | cell activation | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | sensory perception | C-C chemokine receptor activity | regulation of glial cell differentiation | regulation of calcium ion import | lymphocyte proliferation | regulation of response to wounding | regulation of gliogenesis | positive regulation of developmental growth | chemokine receptor activity | signaling | positive regulation of growth | G-protein coupled peptide receptor activity | response to organic cyclic compound | cell development | positive regulation of mesenchymal stem cell migration | regulation of developmental growth | positive regulation of phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of nervous system development | regulation of developmental process | regulation of ion transport | germ cell migration | developmental process | regulation of cell growth | regulation of calcium ion transport | cardiac septum development | detection of temperature stimulus | positive regulation of oligodendrocyte differentiation | tube development | regulation of transport | response to organonitrogen compound | C-X-C chemokine receptor activity | cellular metal ion homeostasis | epithelial cell differentiation | regulation of vascular wound healing | cardiac chamber development | positive regulation of dendrite extension | central nervous system development | response to anesthetic | positive regulation of vascular wound healing | positive regulation of metabolic process | positive regulation of neuron differentiation | cardiac muscle contraction | regulation of cell projection organization | immune system process | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | circulatory system development | chemotaxis | divalent inorganic cation homeostasis | sexual reproduction | positive regulation of angiogenesis | motor neuron axon guidance | regulation of cellular component organization | positive regulation of calcium ion transport | muscle system process | signal transduction | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | late endosome | neuron projection | cytoplasmic vesicle | cell | distal axon | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | cell-cell junction | protein-containing complex | cell projection | endomembrane system | plasma membrane | cell leading edge | vacuole | vesicle | site of polarized growth | lytic vacuole | endosome | membrane-bounded organelle | organelle | lysosome | cell periphery | axon | early endosome | growth cone | intracellular vesicle | cell surface | intracellular | cell junction | membrane
