QuickView for CYLD;jsessionid=90AC1F5AF9F5B6F5E2C8D09BC9C6DB0C;jsessionid=423D30629D4916898B1541D69B8BEE9C (gene)
- Gene Symbol:
- Cyld
Rattus norvegicus - Full name:
- CYLD lysine 63 deubiquitinase
- Synonyms:
- LRRGT00003, Rp1, Rp1h, ubiquitin carboxyl-terminal hydrolase CYLD, cylindromatosis (turban tumor syndrome), deubiquitinating enzyme CYLD, probable ubiquitin carboxyl-terminal hydrolase CYLD, probable ubiquitin carboxyl-terminal hydrolase CYLD-like, retinitis pigmentosa 1 homolog, ubiquitin thioesterase CYLD, ubiquitin thiolesterase CYLD, ubiquitin-specific-processing protease CYLD
- Genomic Location:
- Chr 19: 19593093-19625044
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
E47_01 , AACTTT_UNKNOWN , ATF_01 , CREB_01 , CREBP1CJUN_01 , NFKAPPAB65_01 , CREL_01 , NFKAPPAB_01 , CREB_02 , TAXCREB_01
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
structural molecule activity | kinase binding | cation binding | protein kinase binding | Lys48-specific deubiquitinase activity | enzyme binding | thiol-dependent ubiquitinyl hydrolase activity | hydrolase activity | cysteine-type peptidase activity | catalytic activity | proline-rich region binding | thiol-dependent ubiquitin-specific protease activity | ion binding | Lys63-specific deubiquitinase activity | structural constituent of ribosome | protein binding | ubiquitinyl hydrolase activity | zinc ion binding | transition metal ion binding | metal ion binding | peptidase activity
GO Biological Process
positive regulation of immune response | protein modification by small protein removal | negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | negative regulation of JNK cascade | negative regulation of phosphorylation | negative regulation of MAPK cascade | negative regulation of immune system process | regulation of B cell activation | regulation of cellular localization | positive regulation of apoptotic process | proteolysis | regulation of localization | regulation of programmed cell death | T cell lineage commitment | necroptotic process | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | defense response | negative regulation of protein phosphorylation | positive regulation of cell adhesion | regulation of organelle organization | positive regulation of T cell differentiation | negative regulation of stress-activated protein kinase signaling cascade | cellular process | organic substance catabolic process | lymphocyte differentiation | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | programmed necrotic cell death | immune system development | ripoptosome assembly | regulation of response to cytokine stimulus | Lys48-specific deubiquitinase activity | regulation of cell cycle | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of T cell receptor signaling pathway | regulation of binding | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | catabolic process | negative regulation of p38MAPK cascade | cellular component organization | protein deubiquitination | thiol-dependent ubiquitinyl hydrolase activity | T cell activation | response to stimulus | positive regulation of antigen receptor-mediated signaling pathway | peptide biosynthetic process | regulation of cellular protein localization | positive regulation of immune system process | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | regulation of cilium assembly | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | positive regulation of cell-cell adhesion | programmed cell death | positive regulation of cell activation | cellular protein catabolic process | cellular nitrogen compound metabolic process | protein K48-linked deubiquitination | positive regulation of T cell activation | negative regulation of metabolic process | hemopoiesis | cellular component assembly | negative regulation of hemopoiesis | protein modification process | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | cell-cell signaling | cysteine-type peptidase activity | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | leukocyte differentiation | regulation of cellular response to stress | regulation of cell projection assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | negative regulation of phosphate metabolic process | multicellular organism development | positive regulation of lymphocyte differentiation | regulation of MAPK cascade | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of T cell activation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | protein catabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | negative regulation of DNA-binding transcription factor activity | cellular amide metabolic process | translation | positive regulation of cell differentiation | homeostasis of number of cells | ripoptosome assembly involved in necroptotic process | biosynthetic process | regulation of cellular protein metabolic process | thiol-dependent ubiquitin-specific protease activity | negative regulation of NIK/NF-kappaB signaling | negative regulation of stress-activated MAPK cascade | regulation of apoptotic signaling pathway | negative regulation of cell-cell adhesion | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | negative regulation of cell activation | regulation of tumor necrosis factor-mediated signaling pathway | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | peptide metabolic process | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | Lys63-specific deubiquitinase activity | negative regulation of T cell differentiation | regulation of mitotic cell cycle | regulation of microtubule-based process | lymphocyte activation | T cell differentiation | protein-containing complex assembly | protein metabolic process | protein K63-linked deubiquitination | T cell selection | regulation of hemopoiesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | positive regulation of T cell receptor signaling pathway | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | positive T cell selection | positive regulation of cell death | immune response | organic substance metabolic process | regulation of B cell differentiation | cell death | animal organ development | negative regulation of cellular protein metabolic process | gene expression | amide biosynthetic process | regulation of cell activation | positive regulation of programmed cell death | protein modification by small protein conjugation or removal | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of JNK cascade | cell activation | ubiquitin-dependent protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein linear deubiquitination | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | cellular protein modification process | necrotic cell death | regulation of cell-cell adhesion | innate immune response | negative regulation of Wnt signaling pathway | regulation of cell projection organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | peptidase activity | regulation of protein localization | regulation of cell death | modification-dependent protein catabolic process | regulation of organelle assembly | positive regulation of leukocyte cell-cell adhesion | regulation of microtubule cytoskeleton organization | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | regulation of p38MAPK cascade | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
cytosolic ribosome | supramolecular fiber | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | extrinsic component of membrane | microtubule organizing center | cell | cytoplasmic side of membrane | extrinsic component of plasma membrane | microtubule | cytoplasm | cytoplasmic microtubule | spindle | intracellular organelle | ribosome | centrosome | protein-containing complex | cell projection | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | midbody | cilium | ribonucleoprotein complex | perinuclear region of cytoplasm | microtubule cytoskeleton | small ribosomal subunit | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosolic small ribosomal subunit | cytosol | cytoskeleton | ciliary tip | intracellular | membrane | supramolecular complex | ciliary basal body
