QuickView for CYP24A1;jsessionid=814CDBEFFE05C727B0E5729D232093E4;jsessionid=ACDD8317EE210A9D0D9415DF843AE5F7;jsessionid=09FEC643362BBF866CCBFEB106BA47F1 (gene)
- Gene Symbol:
- Cyp24a1
Mus musculus - Full name:
- cytochrome P450, family 24, subfamily a, polypeptide 1
- Synonyms:
- 24-OHase, CP24, Cyp24, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 25-hydroxyvitamin D-24-hydroxylase, cytochrome P450 24A1, cytochrome P450, 24, cytochrome P450, 24a1, cytochrome P450-CC24, vitamin D(3) 24-hydroxylase
- Genomic Location:
- Chr 2: 170308465-170322638
- Description:
-
The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in ...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CEBPB_02 , AP1FJ_Q2 , AP1_Q2 , NFY_Q6 , NFY_01 , VDR_Q3 , ATF4_Q2 , ALPHACP1_01 , GCTNWTTGK_UNKNOWN , VDR_Q6
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | cofactor binding | vitamin D 24-hydroxylase activity | cation binding | 25-hydroxycholecalciferol-24-hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | ion binding | organic cyclic compound binding | tetrapyrrole binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity
GO Biological Process
response to extracellular stimulus | response to nutrient levels | 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | vitamin D 24-hydroxylase activity | 25-hydroxycholecalciferol-24-hydroxylase activity | organic cyclic compound metabolic process | response to stimulus | response to vitamin D | organic hydroxy compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | response to lipid | small molecule metabolic process | response to nutrient | response to organic substance | vitamin metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | response to vitamin | steroid metabolic process | response to organic cyclic compound | oxidoreductase activity | vitamin D metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | intracellular | membrane
