QuickView for CYP24A1;jsessionid=814CDBEFFE05C727B0E5729D232093E4;jsessionid=ACDD8317EE210A9D0D9415DF843AE5F7;jsessionid=09FEC643362BBF866CCBFEB106BA47F1 (gene)
- Gene Symbol:
- Cyp24a1
Rattus norvegicus - Full name:
- cytochrome P450, family 24, subfamily a, polypeptide 1
- Synonyms:
- 24-OHase, 24R-Ohase, Cyp24, P450-CC24, VITD12, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 25-hydroxyvitamin D3 24-hydroxylase, 25-hydroxyvitaminD324-hydroxylase, Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase), cytochrome P450 24A1, cytochrome P450, subfamily 24, cytochrome P450-CC24, vitamin D(3) 24-hydroxylase
- Genomic Location:
- Chr 3: 161539711-161554157
- Description:
-
enzyme involved in vitamin D metabolism; linked to albuminuria, hyperlipidemia and atherosclerotic aorta lesions
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CEBPB_02 , AP1FJ_Q2 , AP1_Q2 , NFY_Q6 , NFY_01 , VDR_Q3 , ATF4_Q2 , ALPHACP1_01 , GCTNWTTGK_UNKNOWN , VDR_Q6
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | cofactor binding | vitamin D 24-hydroxylase activity | cation binding | 25-hydroxycholecalciferol-24-hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | ion binding | organic cyclic compound binding | tetrapyrrole binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity
GO Biological Process
response to extracellular stimulus | response to nutrient levels | 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | vitamin D 24-hydroxylase activity | cell differentiation | cellular process | organic substance catabolic process | 25-hydroxycholecalciferol-24-hydroxylase activity | catabolic process | organic cyclic compound metabolic process | response to stimulus | response to vitamin D | organic hydroxy compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | steroid catabolic process | lipid metabolic process | response to lipid | small molecule metabolic process | response to nutrient | response to organic substance | vitamin metabolic process | metabolic process | oxidation-reduction process | lipid catabolic process | organic substance metabolic process | response to vitamin | steroid metabolic process | response to organic cyclic compound | vitamin D catabolic process | developmental process | ossification | osteoblast differentiation | cellular metabolic process | oxidoreductase activity | vitamin D metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | intracellular | membrane
