QuickView for Csn8;jsessionid=63E186AD2E4B83AA7CDA0386F0AE6E90 (gene)

Gene Symbol:

COPS8 Homo sapiens

Full name:

COP9 signalosome subunit 8

Synonyms:

COP9, CSN8, SGN8, COP9 signalosome complex subunit 8, COP9 constitutive photomorphogenic homolog subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8, hCOP9, signalosome subunit 8

Genomic Location:

Chr 2: 237658823-237672228

Description:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact...

View Full Description

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GCATTTG_MIR105 ,  CAGTATT_MIR200B_MIR200C_MIR429

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b

Cytogenetic Map:

2q37.3

search → result