QuickView for DCK;jsessionid=6EBD80B6C8AA59311B53DD1B5C8A88C0;jsessionid=6D0600F578E48C641CA4756BE79F6A18;jsessionid=699D037B1DFAF8F443EA76DCB130DA67;jsessionid=28CA813A9C7DBDC4B4208FDC45954C74 (gene)
- Gene Symbol:
- DCK
Homo sapiens - Full name:
- deoxycytidine kinase
- Synonyms:
- deoxycytidine kinase, deoxynucleoside kinase
- Genomic Location:
- Chr 4: 72078256-72115477
- Description:
-
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotox...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
RYTTCCTG_ETS2_B , E2F1_Q4_01 , E2F4DP1_01 , E2F_Q6_01 , E2F_Q6 , E2F_Q4 , E2F1DP2_01 , E2F1_Q3_01 , E2F_03 , E2F1DP1_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
4q13.3
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | nucleoside kinase activity | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | nucleobase-containing compound kinase activity | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | deoxynucleoside kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | deoxycytidine kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
pyrimidine nucleoside biosynthetic process | pyrimidine nucleoside metabolic process | deoxyribonucleoside monophosphate biosynthetic process | cellular process | nucleotide metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | pyrimidine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cellular biosynthetic process | nucleotide biosynthetic process | nitrogen compound metabolic process | phosphorus metabolic process | nucleoside kinase activity | organophosphate metabolic process | nucleoside metabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | nucleobase-containing compound kinase activity | phosphate-containing compound metabolic process | pyrimidine nucleoside salvage | pyrimidine-containing compound salvage | metabolic process | deoxynucleoside kinase activity | nucleobase-containing compound metabolic process | organic substance metabolic process | purine-containing compound salvage | kinase activity | deoxycytidine kinase activity | carbohydrate derivative metabolic process | heterocycle metabolic process | cellular metabolic process | nucleoside monophosphate biosynthetic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular
