QuickView for DCLK2;jsessionid=E5CD43FAAD836852FBE2A6E6A3A9F483;jsessionid=82D7CDC1929F0F53B2E3A3B3C57F5503;jsessionid=82E7BBBE07EB6DF5F492825E1AB646C2 (gene)

Gene Symbol:

Dclk2 Mus musculus

Full name:

doublecortin-like kinase 2

Synonyms:

6330415M09Rik, AU044875, CL2, CLICK2, Click-II, Dcamkl2, serine/threonine-protein kinase DCLK2, caMK-like CREB regulatory kinase 2, doublecortin and CaM kinase-like 2, doublecortin-like and CAM kinase-like 2

Genomic Location:

Chr 3: 86590075-86724774

Description:

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent ...

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This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6 ,  LMO2COM_01 ,  TCF11_01 ,  AREB6_04 ,  E12_Q6 ,  LEF1_Q6 ,  MYOD_Q6_01 ,  DR4_Q2 ,  TAATAAT_MIR126 ,  CAGGTG_E12_Q6 ,  CTTTGT_LEF1_Q2 ,  GCANCTGNY_MYOD_Q6 ,  TGGAAA_NFAT_Q4_01 ,  CATTGTYY_SOX9_B1

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