QuickView for DCLK2;jsessionid=E5CD43FAAD836852FBE2A6E6A3A9F483;jsessionid=82D7CDC1929F0F53B2E3A3B3C57F5503;jsessionid=06CC5E6720AEC2EF8EF90D48E2FEEED8 (gene)

Gene Symbol:

Dclk2 Rattus norvegicus

Full name:

doublecortin-like kinase 2

Synonyms:

CL2, CLICK-II, CLICK2, Dck2, RGD1308384, serine/threonine-protein kinase DCLK2, caMK-like CREB regulatory kinase 2, doublecortin kinase 2, doublecortin-like and CAM kinase-like 2

Genomic Location:

Chr 2: 178793765-178923600

Description:

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent ...

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This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that this gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Homo sapiens ,  Mus musculus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6 ,  LMO2COM_01 ,  TCF11_01 ,  AREB6_04 ,  E12_Q6 ,  LEF1_Q6 ,  MYOD_Q6_01 ,  DR4_Q2 ,  TAATAAT_MIR126 ,  CAGGTG_E12_Q6 ,  CTTTGT_LEF1_Q2 ,  GCANCTGNY_MYOD_Q6 ,  TGGAAA_NFAT_Q4_01 ,  CATTGTYY_SOX9_B1

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