QuickView for DIAPH1;jsessionid=C59682E27A95FA747380E0AD4B940900;jsessionid=60EBDD339A031759172A7440CC171CDA (gene)

Gene Symbol:

Diaph1 Mus musculus

Full name:

diaphanous related formin 1

Synonyms:

D18Wsu154e, Dia1, Diap1, Drf1, p140mDia, protein diaphanous homolog 1

Genomic Location:

Chr 18: 38004478-38095065

Description:

This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary ...

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This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary lymphoid organs and egression of thymocytes from the thymus are impaired in these animals. Lack of the encoded protein in T lymphocytes and thymocytes also reduces chemotaxis. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  NFE2_01 ,  TAXCREB_02 ,  MYCMAX_01 ,  AP1FJ_Q2 ,  AP1_Q6 ,  USF_Q6 ,  AP1_Q4 ,  CATRRAGC_UNKNOWN ,  NGFIC_01 ,  EGR2_01 ,  MYCMAX_B ,  ZF5_B ,  GABP_B ,  AREB6_01 ,  BACH1_01 ,  ERR1_Q2 ,  POU1F1_Q6 ,  USF_Q6_01 ,  EGR_Q6 ,  AP1_Q6_01 ,  DR3_Q4 ,  AGGAAGC_MIR5163P ,  RAAGNYNNCTTY_UNKNOWN ,  ACCAAAG_MIR9 ,  TGCCTTA_MIR124A ,  RNGTGGGC_UNKNOWN ,  TGCAAAC_MIR452 ,  TCCATTKW_UNKNOWN ,  TGCTGAY_UNKNOWN ,  YGCGYRCGC_UNKNOWN ,  TGANTCA_AP1_C ,  CAGGTA_AREB6_01 ,  SCGGAAGY_ELK1_02 ,  TGACCTY_ERR1_Q2 ,  MGGAAGTG_GABP_B ,  GGGAGGRR_MAZ_Q6 ,  CACGTG_MYC_Q2 ,  TGGAAA_NFAT_Q4_01 ,  GGGCGGR_SP1_Q6 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-452

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