QuickView for DMPK;jsessionid=49656AD0353459F0AF7D57856507C411;jsessionid=64D1D823338752EF8ABA2FE1A103A6A9;jsessionid=44B1CB53AE7F30299A7F80426328C48C;jsessionid=73771DAD8F45A464FDF4BAC85C97D208;jsessionid=F133DC148A52A6E8D8F3959D4A2E6647;jsessionid=3C280F6BB438109AB3093F5851D7FCEF (gene)

Gene Symbol:

Dmpk Mus musculus

Full name:

dystrophia myotonica-protein kinase

Synonyms:

DM, DMK, Dm15, MDPK, MT-PK, myotonin-protein kinase, DM-kinase, dystrophia myotonica kinase, B15, myotonic dystrophy protein kinase

Genomic Location:

Chr 7: 19669344-19678451

Description:

The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeleta...

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The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E47_02 ,  LYF1_01 ,  ARGGGTTAA_UNKNOWN ,  AP1_Q6 ,  MYOD_Q6 ,  SRF_Q6 ,  SRF_C ,  TATA_01 ,  FREAC7_01 ,  MMEF2_Q6 ,  AREB6_02 ,  AP2ALPHA_01 ,  TBP_01 ,  MAZR_01 ,  AFP1_Q6 ,  CRX_Q4 ,  LFA1_Q6 ,  E12_Q6 ,  SMAD3_Q6 ,  GCCNNNWTAAR_UNKNOWN ,  MYOGENIN_Q6 ,  OSF2_Q6 ,  AP2_Q6_01 ,  AP1_Q6_01 ,  ACATTCC_MIR1_MIR206 ,  TCCCCAC_MIR491 ,  CCTGTGA_MIR513 ,  RNGTGGGC_UNKNOWN ,  SMTTTTGT_UNKNOWN ,  WWTAAGGC_UNKNOWN ,  TGANTCA_AP1_C ,  CAGCTG_AP4_Q5 ,  CAGGTG_E12_Q6 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  YTATTTTNR_MEF2_02 ,  GCANCTGNY_MYOD_Q6 ,  CCCNNGGGAR_OLF1_01 ,  GGGTGGRR_PAX4_03 ,  GGATTA_PITX2_Q2 ,  TATAAA_TATA_01 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-491

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