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QuickView for DNM1L;jsessionid=15F77E6889E1CDC1AF31BCFDCB4CFEA1;jsessionid=BA0585602D7AED53BA3162EA7BE1EEDD (gene)


Gene Symbol:
Dnm1l Mus musculus Mus musculus
Full name:
dynamin 1-like
Synonyms:
6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, python, dynamin-1-like protein, dymple, dynamin family member proline-rich carboxyl-terminal domain less, dynamin-related protein 1
Genomic Location:
Chr 16: 16312326-16359123
Description:
This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2.
Orthologs:
Homo sapiens Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

BH2 domain binding | guanyl ribonucleotide binding | GTPase binding | ribonucleoside binding | clathrin binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | lipid binding | nucleotide binding | hydrolase activity | GTP-dependent protein binding | carbohydrate derivative binding | pyrophosphatase activity | Ras GTPase binding | catalytic activity | protein domain specific binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity | GTP binding | hydrolase activity, acting on acid anhydrides | small GTPase binding | Rab GTPase binding | microtubule binding | nucleoside binding | purine ribonucleotide binding | tubulin binding | BH domain binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

protein homooligomerization | heart process | peroxisome organization | release of cytochrome c from mitochondria | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cellular localization | positive regulation of apoptotic process | regulation of cell development | protein localization to mitochondrion | regulation of localization | peroxisome fission | regulation of programmed cell death | regulation of mitochondrial fission | necroptotic process | establishment of localization | regulation of autophagy | negative regulation of cellular process | positive regulation of neurotransmitter secretion | membrane fusion | positive regulation of developmental process | cell differentiation | positive regulation of intrinsic apoptotic signaling pathway | nervous system development | negative regulation of mitochondrion organization | cell part morphogenesis | neurogenesis | cellular response to thapsigargin | regulation of protein oligomerization | regulation of organelle organization | generation of neurons | positive regulation of protein secretion | membrane organization | intracellular transport | positive regulation of dendritic spine morphogenesis | cellular process | establishment of organelle localization | regulation of dendritic spine morphogenesis | localization | mitochondrial fragmentation involved in apoptotic process | positive regulation of synaptic transmission | programmed necrotic cell death | macromolecule localization | positive regulation of release of cytochrome c from mitochondria | regulation of neuron projection development | establishment of localization in cell | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | organelle localization | heart contraction | cellular component organization | regulation of mitochondrial fusion | positive regulation of dendrite morphogenesis | mitochondrion morphogenesis | regulation of peptide secretion | response to stimulus | positive regulation of synaptic vesicle recycling | positive regulation of synaptic vesicle exocytosis | programmed cell death | cellular localization | apoptotic mitochondrial changes | cellular response to organic cyclic compound | regulation of protein transport | blood circulation | cellular component assembly | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | mitochondrion organization | regulation of intracellular transport | positive regulation of mitochondrion organization | positive regulation of peptide secretion | positive regulation of exocytosis | regulation of neurotransmitter levels | apoptotic process | synaptic vesicle cycle | system development | regulation of signal transduction | positive regulation of organelle organization | positive regulation of neuron projection development | multicellular organism development | regulation of synaptic vesicle exocytosis | protein complex oligomerization | regulation of intrinsic apoptotic signaling pathway | synaptic vesicle recycling | regulation of neuron differentiation | positive regulation of secretion | response to lipid | synaptic vesicle recycling via endosome | membrane fission | regulation of synapse organization | regulation of nitrogen compound metabolic process | positive regulation of cell projection organization | protein polymerization | positive regulation of intracellular signal transduction | vesicle-mediated transport | protein homotetramerization | protein localization to organelle | positive regulation of cell differentiation | mitochondrion localization | establishment of vesicle localization | cellular protein-containing complex assembly | regulation of synaptic vesicle endocytosis | protein tetramerization | regulation of synaptic vesicle transport | regulation of apoptotic signaling pathway | positive regulation of dendritic spine development | positive regulation of regulated secretory pathway | regulation of mitochondrion organization | regulation of peroxisome organization | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | positive regulation of establishment of protein localization | positive regulation of transport | apoptotic signaling pathway | positive regulation of dendrite development | regulation of autophagy of mitochondrion | mitochondrion distribution | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | negative regulation of mitochondrial fusion | regulation of establishment of protein localization | response to organic substance | import into cell | regulation of intracellular signal transduction | regulation of exocytosis | anatomical structure development | regulation of dendrite morphogenesis | positive regulation of neurogenesis | positive regulation of cell development | positive regulation of calcium ion-dependent exocytosis | cellular protein localization | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | positive regulation of cell death | dynamin family protein polymerization involved in mitochondrial fission | cell death | intracellular distribution of mitochondria | regulation of protein secretion | positive regulation of programmed cell death | regulation of ATP metabolic process | regulation of phosphate metabolic process | regulation of regulated secretory pathway | positive regulation of intracellular transport | regulation of postsynapse organization | positive regulation of protein transport | regulation of dendrite development | regulation of cell communication | regulation of dendritic spine development | signaling | response to organic cyclic compound | regulation of endocytosis | positive regulation of mitochondrial fission | protein localization | anatomical structure morphogenesis | cellular macromolecule localization | regulation of synaptic vesicle recycling | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | mitochondrial membrane fission | regulation of transport | necrotic cell death | regulation of calcium ion-dependent exocytosis | vesicle localization | positive regulation of neuron differentiation | mitochondrial fission | regulation of cell projection organization | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell morphogenesis involved in differentiation | positive regulation of endocytosis | positive regulation of synaptic vesicle endocytosis | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | regulation of neurotransmitter secretion | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | mitochondrion-derived vesicle | brush border | intracellular membrane-bounded organelle | synapse | organelle membrane | peroxisome | cytoplasmic vesicle | cell | organelle outer membrane | microtubule | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | protein-containing complex | secretory vesicle | endomembrane system | vesicle | perinuclear region of cytoplasm | clathrin-coated pit | microtubule cytoskeleton | mitochondrion | Golgi membrane | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | mitochondrial membrane | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex