QuickView for DNMT;jsessionid=9B6CC5497F71E2B638B92D9B318AC724;jsessionid=BF89EA64E37219B69A3F633115BA8F96 (gene)

Gene Symbol:

Dnmt1 Mus musculus

Full name:

DNA methyltransferase (cytosine-5) 1

Synonyms:

Cxxc9, Dnmt, Dnmt1o, MCMT, MTase, Met-1, Met1, MommeD2, m.MmuI, DNA (cytosine-5)-methyltransferase 1, DNA MTase MmuI, DNA methyltransferase MmuI

Genomic Location:

Chr 9: 20711653-20757317

Description:

This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-...

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This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E2F_01 ,  CETS1P54_01 ,  E2F_02 ,  NRF2_01 ,  E2F_Q3 ,  E2F_Q4 ,  E2F_Q6 ,  E2F1_Q3 ,  E2F1_Q6 ,  E2F_03 ,  NRF1_Q6 ,  E2F1DP1_01 ,  E2F1DP2_01 ,  E2F4DP1_01 ,  E2F4DP2_01 ,  E2F1DP1RB_01 ,  E2F_Q3_01 ,  E2F_Q4_01 ,  E2F_Q6_01 ,  E2F1_Q3_01 ,  E2F1_Q4_01 ,  E2F1_Q6_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TGCGCANK_UNKNOWN ,  SGCGSSAAA_E2F1DP2_01 ,  SCGGAAGY_ELK1_02 ,  RYTTCCTG_ETS2_B ,  MGGAAGTG_GABP_B ,  GGGAGGRR_MAZ_Q6 ,  TGACAGNY_MEIS1_01 ,  RCGCANGCGY_NRF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148

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