QuickView for DNMT;jsessionid=9B6CC5497F71E2B638B92D9B318AC724;jsessionid=A6770B8B604453C9832A147A24BCA56C (gene)
- Gene Symbol:
- Dnmt1
Rattus norvegicus - Full name:
- DNA methyltransferase 1
- Synonyms:
- DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5-)-methyltransferase 1, DNA MTase RnoIP, DNA methyltransferase (cytosine-5) 1, DNA methyltransferase I, MCMT, m.RnoIP
- Genomic Location:
- Chr 8: 19927666-19973220
- Description:
-
methylates genomic DNA; involved in processes of gene inactivation, chromatin organization, X chromosome inactivation and genomic imprinting
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
sequence-specific DNA binding | cation binding | hormone receptor binding | enzyme binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | nucleotide binding | estrogen receptor binding | signaling receptor binding | catalytic activity | chromatin binding | protein domain specific binding | DNA binding | promoter-specific chromatin binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | protein binding | zinc ion binding | transcription factor binding | DNA-methyltransferase activity | transferase activity | transition metal ion binding | steroid hormone receptor binding | DNA (cytosine-5-)-methyltransferase activity | methyltransferase activity | methyl-CpG binding | histone deacetylase binding | metal ion binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | negative regulation of smooth muscle cell apoptotic process | brain development | response to radiation | response to nutrient levels | positive regulation of cellular component organization | response to lipopolysaccharide | intracellular signal transduction | cellular response to platelet-derived growth factor stimulus | sulfur compound metabolic process | regulation of programmed cell death | regulation of DNA methylation | response to hormone | DNA modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | nervous system development | response to drug | regulation of phenotypic switching | neurogenesis | regulation of organelle organization | generation of neurons | response to antibiotic | positive regulation of vascular smooth muscle cell proliferation | cellular process | chromatin organization | DNA methylation involved in embryo development | response to estradiol | regulation of methylation-dependent chromatin silencing | regulation of histone H3-K9 methylation | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of apoptotic process | negative regulation of phenotypic switching | response to growth factor | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | S-adenosylmethionine metabolic process | regulation of cell differentiation | negative regulation of histone methylation | regulation of cellular process | regulation of apoptotic process | gene silencing | regulation of metabolic process | response to nerve growth factor | S-adenosylmethionine-dependent methyltransferase activity | small GTPase mediated signal transduction | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | response to transforming growth factor beta | positive regulation of chromatin silencing | cellular response to metal ion | head development | regulation of histone methylation | regulation of vasculature development | response to stimulus | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular response to inorganic substance | response to alcohol | response to temperature stimulus | response to molecule of bacterial origin | regulation of gene silencing | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cofactor metabolic process | cellular biosynthetic process | embryo development | macromolecule modification | response to ethanol | regulation of nucleic acid-templated transcription | response to nitrogen compound | response to external biotic stimulus | system development | nitrogen compound metabolic process | positive regulation of organelle organization | multicellular organism development | response to activity | response to amino acid | response to purine-containing compound | cellular response to nerve growth factor stimulus | positive regulation of chromosome organization | regulation of gene expression | negative regulation of histone H3-K9 methylation | methylation | response to ketone | response to lipid | positive regulation of cellular metabolic process | regulation of smooth muscle cell differentiation | positive regulation of methylation-dependent chromatin silencing | regulation of nitrogen compound metabolic process | cellular response to lead ion | regulation of transcription by RNA polymerase II | DNA methylation | response to nutrient | regulation of smooth muscle cell apoptotic process | DNA methylation on cytosine | response to platelet-derived growth factor | negative regulation of smooth muscle cell differentiation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | response to vitamin A | response to toxic substance | response to xenobiotic stimulus | cellular response to amino acid stimulus | response to bacterium | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | response to testosterone | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | regulation of histone H3-K4 methylation | DNA methylation on cytosine within a CG sequence | positive regulation of cell proliferation | negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching | regulation of RNA metabolic process | drug metabolic process | cellular response to transforming growth factor beta stimulus | neuron differentiation | positive regulation of protein modification process | response to organic substance | DNA-methyltransferase activity | C-5 methylation of cytosine | DNA hypermethylation | DNA metabolic process | anatomical structure development | metabolic process | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of muscle cell apoptotic process | negative regulation of vascular associated smooth muscle cell apoptotic process | nucleobase-containing compound metabolic process | response to caffeine | organic substance metabolic process | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | response to heat | regulation of chromosome organization | response to alkaloid | negative regulation of vascular smooth muscle cell differentiation | transcription, DNA-templated | maintenance of DNA methylation | negative regulation of protein metabolic process | negative regulation of chromosome organization | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of developmental process | DNA (cytosine-5-)-methyltransferase activity | methyltransferase activity | positive regulation of DNA metabolic process | developmental process | organelle organization | regulation of muscle cell differentiation | negative regulation of transcription by RNA polymerase II | negative regulation of vasculature development | Ras protein signal transduction | response to organonitrogen compound | heterocycle metabolic process | response to lead ion | central nervous system development | negative regulation of muscle cell differentiation | positive regulation of metabolic process | chromosome organization | positive regulation of histone methylation | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of cell death | aging | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | response to other organism | signal transduction | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | somatodendritic compartment | chromosome, centromeric region | cell body | cell | neuronal cell body | replication fork | cytoplasm | intracellular organelle | protein-containing complex | chromatin | pericentric heterochromatin | membrane-bounded organelle | heterochromatin | nucleus | organelle | intracellular
