QuickView for DRD4;jsessionid=0111561E95A1D117439E0005A0EFAD17;jsessionid=1B65586380A7E512E1B5C7D7AA38F24C;jsessionid=0D5338CC8445C33065703A4AB1A85711 (gene)

Gene Symbol:

DRD4 Homo sapiens

Full name:

dopamine receptor D4

Synonyms:

D4DR, D(4) dopamine receptor, D(2C) dopamine receptor, dopamine D4 receptor, seven transmembrane helix receptor

Genomic Location:

Chr 11: 627305-630703

Description:

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention...

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This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGACGY_E4F1_Q6 ,  ATF_01

Cytogenetic Map:

11p15.5

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