QuickView for DSCR1;jsessionid=AF4B539CBFFE018868F7419811B11685;jsessionid=22D22A56734BC68EAF626F74583DBD02 (gene)
- Gene Symbol:
- RCAN1
Homo sapiens - Full name:
- regulator of calcineurin 1
- Synonyms:
- ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1, calcipressin-1, Down syndrome candidate region 1, Down syndrome critical region gene 1, calcium and oxidant-inducible mRNA, modulatory calcineurin-interacting protein 1, myocyte-enriched calcineurin-interacting protein 1, near DSCR proline-rich protein
- Genomic Location:
- Chr 21: 34810652-34909252
- Description:
-
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this g...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
21q22.12
GO Molecular Function
nucleic acid binding | molecular function regulator | DNA binding | calcium-dependent protein serine/threonine phosphatase regulator activity | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | protein phosphatase regulator activity | enzyme regulator activity | heterocyclic compound binding | phosphatase regulator activity
GO Biological Process
regulation of dephosphorylation | intracellular signal transduction | negative regulation of cellular process | regulation of phosphatase activity | nervous system development | inositol phosphate-mediated signaling | cellular process | negative regulation of calcineurin-mediated signaling | regulation of calcium-mediated signaling | negative regulation of signaling | regulation of cellular process | regulation of metabolic process | negative regulation of calcium-mediated signaling | response to stimulus | blood circulation | molecular function regulator | regulation of nucleic acid-templated transcription | system development | regulation of signal transduction | multicellular organism development | regulation of catalytic activity | regulation of gene expression | regulation of nitrogen compound metabolic process | calcium-dependent protein serine/threonine phosphatase regulator activity | negative regulation of calcineurin-NFAT signaling cascade | second-messenger-mediated signaling | regulation of cellular protein metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of RNA metabolic process | calcium-mediated signaling | DNA-binding transcription factor activity | regulation of protein dephosphorylation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of RNA biosynthetic process | protein phosphatase regulator activity | regulation of calcineurin-NFAT signaling cascade | calcineurin-mediated signaling | regulation of phosphate metabolic process | calcineurin-NFAT signaling cascade | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | enzyme regulator activity | regulation of phosphoprotein phosphatase activity | developmental process | central nervous system development | phosphatase regulator activity | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
