QuickView for EIF4G;jsessionid=EED488403BD997C239726CDE2C49EEB1 (gene)

Gene Symbol:

Eif4g1 Mus musculus

Full name:

eukaryotic translation initiation factor 4, gamma 1

Synonyms:

E030015G23Rik, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, eIF4GI, eukaryotic translation initiation factor 4 gamma 1

Genomic Location:

Chr 16: 20672822-20692956

Description:

This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the ...

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This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  ELK1_01 ,  ELK1_02 ,  NFE2_01 ,  NFKAPPAB65_01 ,  CREL_01 ,  NMYC_01 ,  HEN1_02 ,  YY1_02 ,  GATA2_01 ,  MZF1_01 ,  USF_01 ,  HNF4_01 ,  AP1FJ_Q2 ,  AP1_Q2 ,  USF_Q6 ,  AP1_Q4 ,  USF_C ,  SREBP1_01 ,  HAND1E47_01 ,  RREB1_01 ,  TCF11MAFG_01 ,  HNF4_01_B ,  AREB6_04 ,  SPZ1_01 ,  ZIC1_01 ,  FOXO4_01 ,  FOXO1_02 ,  PAX2_02 ,  BACH2_01 ,  MAZR_01 ,  STAT1_02 ,  BACH1_01 ,  STAT1_03 ,  STAT3_02 ,  ATF4_Q2 ,  ARNT_02 ,  MYCMAX_03 ,  HNF4ALPHA_Q6 ,  PTF1BETA_Q6 ,  SP3_Q3 ,  AP3_Q6 ,  CACBINDINGPROTEIN_Q6 ,  HFH4_01 ,  HMGIY_Q6 ,  DR1_Q3 ,  PPAR_DR1_Q2 ,  USF_Q6_01 ,  HIF1_Q3 ,  NRF2_Q4 ,  AP1_Q2_01 ,  AP1_Q6_01 ,  E2F1_Q3_01 ,  DR4_Q2 ,  CGCTGCT_MIR503 ,  ACTGCAG_MIR173P ,  CCTGCTG_MIR214 ,  GGCAGTG_MIR3243P ,  RACTNNRTTTNC_UNKNOWN ,  GGTGTGT_MIR329 ,  SYATTGTG_UNKNOWN ,  TGANTCA_AP1_C ,  CAGGTA_AREB6_01 ,  TTGTTT_FOXO4_01 ,  AAAYWAACM_HFH4_01 ,  CTTTGA_LEF1_Q2 ,  CTTTGT_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  CACGTG_MYC_Q2 ,  TGCCAAR_NF1_Q6 ,  TGGAAA_NFAT_Q4_01 ,  TGASTMAGC_NFE2_01 ,  GGGTGGRR_PAX4_03 ,  GGGCGGR_SP1_Q6 ,  TCANNTGAY_SREBP1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-503

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